ArticleBrain sciences2024
Prefrontal Cortex Responses to Social Video Stimuli in Young Children with and without Autism Spectrum Disorder.
Article in Brain sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Using Wearables in Mental Health Care for Children and Adolescents: A Scoping Review.Research on child and adolescent psychopathology · 2026Article
- Lean-NET-Based Local Brain Connectome Analysis for Autism Spectrum Disorder Classification.Bioengineering (Basel, Switzerland) · 2026Article
- Anterior insular cortex regulates depression-like and ASD-like behaviors via the differential contribution of two subsets of microglia.Molecular psychiatry · 2026Article
- The Impact of the COVID-19 Pandemic on Young Adults with Autism Spectrum Disorder: A Systematic Review.Healthcare (Basel, Switzerland) · 2025Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting individuals worldwide and characterized by deficits in social interaction along with the presence of restricted interest and repetitive behaviors. Despite decades of behavioral research, little is known about the brain mechanisms that influence social behaviors among children with ASD. This, in part, is due to limitations of traditional imaging techniques specifically targeting pediatric populations. As a portable and scalable optical brain monitoring technology, functional near infrared spectroscopy (fNIRS) provides a measure of cerebral hemodynamics related to sensory, motor, or cognitive function. Here, we utilized fNIRS to investigate the prefrontal cortex (PFC) activity of young children with ASD and with typical development while they watched social and nonsocial video clips. The PFC activity of ASD children was significantly higher for social stimuli at medial PFC, which is implicated in social cognition/processing. Moreover, this activity was also consistently correlated with clinical measures, and higher activation of the same brain area only during social video viewing was associated with more ASD symptoms. This is the first study to implement a neuroergonomics approach to investigate cognitive load in response to realistic, complex, and dynamic audiovisual social stimuli for young children with and without autism. Our results further confirm that new generation of portable fNIRS neuroimaging can be used for ecologically valid measurements of the brain function of toddlers and preschool children with ASD.
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Registered trials
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