Evidence map›Paper›PMID 38790389›Full record

ArticleBrain sciences2024

Is Virtual Reality Orientation Therapy Useful to Optimize Cognitive and Behavioral Functioning Following Severe Acquired Brain Injury? An Exploratory Study.

Rosaria De Luca, Andrea Calderone, Antonio Gangemi, Carmela Rifici, Mirjam Bonanno, Maria Grazia Maggio, Irene Cappadona, Isabella Veneziani, Augusto Ielo, Francesco Corallo and 3 more

Registry-linked trialAbstract read
In one paragraph

Article in Brain sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07386314 (Motor and Cognitive Telerehabilitation for Acquired Brain Injury), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07386314 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Motor and Cognitive Telerehabilitation for Acquired Brain Injury

TypeinterventionalSponsorAzienda USL Toscana Nord OvestRan2026 to 2026Enrolled62ConditionsAcquired Brain InjuryArmsTele-rehabilitation, Group Presence
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rosaria De LucaIRCCS Centro Neurolesi Bonino-Pulejo, S.S. 113 Via Palermo, C. da Casazza, 98124 Messina, Italy.ORCID 0000-0001-9503-4366
Andrea CalderoneIRCCS Centro Neurolesi Bonino-Pulejo, S.S. 113 Via Palermo, C. da Casazza, 98124 Messina, Italy.
Antonio GangemiIRCCS Centro Neurolesi Bonino-Pulejo, S.S. 113 Via Palermo, C. da Casazza, 98124 Messina, Italy.
Carmela RificiIRCCS Centro Neurolesi Bonino-Pulejo, S.S. 113 Via Palermo, C. da Casazza, 98124 Messina, Italy.
Mirjam BonannoIRCCS Centro Neurolesi Bonino-Pulejo, S.S. 113 Via Palermo, C. da Casazza, 98124 Messina, Italy.ORCID 0000-0002-3284-9741
Maria Grazia MaggioIRCCS Centro Neurolesi Bonino-Pulejo, S.S. 113 Via Palermo, C. da Casazza, 98124 Messina, Italy.ORCID 0000-0003-0757-2389
Irene CappadonaIRCCS Centro Neurolesi Bonino-Pulejo, S.S. 113 Via Palermo, C. da Casazza, 98124 Messina, Italy.ORCID 0000-0002-3984-2331
Isabella VenezianiDepartment of Nervous System and Behavioural Sciences, Psychology Section, University of Pavia, Piazza Botta, 11, 27100 Pavia, Italy.ORCID 0009-0003-0007-1853
Augusto IeloIRCCS Centro Neurolesi Bonino-Pulejo, S.S. 113 Via Palermo, C. da Casazza, 98124 Messina, Italy.ORCID 0000-0001-9661-9681
Francesco CoralloIRCCS Centro Neurolesi Bonino-Pulejo, S.S. 113 Via Palermo, C. da Casazza, 98124 Messina, Italy.ORCID 0000-0003-4862-3832
Angelo QuartaroneIRCCS Centro Neurolesi Bonino-Pulejo, S.S. 113 Via Palermo, C. da Casazza, 98124 Messina, Italy.
Davide CardileIRCCS Centro Neurolesi Bonino-Pulejo, S.S. 113 Via Palermo, C. da Casazza, 98124 Messina, Italy.ORCID 0000-0003-2052-0970
Rocco Salvatore CalabròIRCCS Centro Neurolesi Bonino-Pulejo, S.S. 113 Via Palermo, C. da Casazza, 98124 Messina, Italy.ORCID 0000-0002-8566-3166

Funding

Ministero della Salute Current Research Funds 2024
6 · The paper itself

Abstract

introductionSevere acquired brain injury (SABI) is a leading cause of death and disability, and it is defined as a brain injury that occurs after birth due to traumatic or non-traumatic causes. Reality orientation therapy (ROT) uses repeated time-place-person orientation and meaningful stimuli to develop a better understanding of the environment and has great potential as an effective strategy to improve cognitive and behavioral functioning.

objectiveThis study aims to investigate the feasibility and potential effects of virtual reality orientation therapy (VR-rot) on optimizing cognitive and behavioral functioning and depressive symptoms post-SABI.

methodForty patients with SABI were enrolled from October 2022 to December 2023 and divided into two groups: the experimental group (EG,

resultsWithin-group comparisons indicated a statistically significant change in MMSE scores from T0 to T1 in the EG and CG, with the EG showing a greater improvement than the CG. Regarding HRS-D scores, the EG showed a statistically significant change. VR-ROT could be a valuable tool for improving cognitive-behavioral functioning in SABI patients.

conclusionsThe VRRS can help reduce depressive symptoms and improve the reality orientation deficit caused by traumatic brain injury and stroke on brain tissue. This study highlights the benefits of virtual reality.

Indexed as

cognitive deficitsdepressive symptomsROT (reality orientation therapy)SABIvirtual reality rehabilitation

Identifiers

PMID38790389
PMCPMC11119343

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.