Evidence map›Paper›PMID 38790353›Full record

ReviewBioengineering (Basel, Switzerland)2024

Updated Toolbox for Assessing Neuronal Network Reconstruction after Cell Therapy.

Ana Gonzalez-Ramos, Claudia Puigsasllosas-Pastor, Ainhoa Arcas-Marquez, Daniel Tornero

Abstract readReview
In one paragraph

Review in Bioengineering (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ana Gonzalez-RamosStanley Center for Psychiatric Research at Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0001-8569-5566
Claudia Puigsasllosas-PastorLaboratory of Neural Stem Cells and Brain Damage, Department of Biomedical Sciences, Institute of Neurosciences, University of Barcelona, 08036 Barcelona, Spain.ORCID 0009-0007-6498-5223
Ainhoa Arcas-MarquezLaboratory of Neural Stem Cells and Brain Damage, Department of Biomedical Sciences, Institute of Neurosciences, University of Barcelona, 08036 Barcelona, Spain.ORCID 0000-0001-9110-1787
Daniel TorneroLaboratory of Neural Stem Cells and Brain Damage, Department of Biomedical Sciences, Institute of Neurosciences, University of Barcelona, 08036 Barcelona, Spain.ORCID 0000-0002-4812-4091

Funding

Knut and Alice Wallenberg Foundation KAW 2022.0353Ministerio de Ciencia e Innovación PID2020-118120RB-I00Ministerio de Ciencia e Innovación PRE2021-098786
6 · The paper itself

Abstract

Cell therapy has proven to be a promising treatment for a range of neurological disorders, including Parkinson Disease, drug-resistant epilepsy, and stroke, by restoring function after brain damage. Nevertheless, evaluating the true effectiveness of these therapeutic interventions requires a deep understanding of the functional integration of grafted cells into existing neural networks. This review explores a powerful arsenal of molecular techniques revolutionizing our ability to unveil functional integration of grafted cells within the host brain. From precise manipulation of neuronal activity to pinpoint the functional contribution of transplanted cells by using opto- and chemo-genetics, to real-time monitoring of neuronal dynamics shedding light on functional connectivity within the reconstructed circuits by using genetically encoded (calcium) indicators

Indexed as

calcium imagingcell therapychemogeneticsDREADDfunctional connectivityindicatormonosynaptic tracingoptogeneticsrabies virussensor

Identifiers

PMID38790353
PMCPMC11118929

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.