Evidence map›Paper›PMID 38790307›Full record

ArticleBioengineering (Basel, Switzerland)2024

Unveiling the Unpredictable in Parkinson's Disease: Sensor-Based Monitoring of Dyskinesias and Freezing of Gait in Daily Life.

Alessandro Zampogna, Luigi Borzì, Domiziana Rinaldi, Carlo Alberto Artusi, Gabriele Imbalzano, Martina Patera, Leonardo Lopiano, Francesco Pontieri, Gabriella Olmo, Antonio Suppa

Abstract read
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alessandro ZampognaDepartment of Human Neurosciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-0227-1993
Luigi BorzìData Analytics and Technologies for Health Lab (ANTHEA), Department of Control and Computer Engineering, Politecnico di Torino, 10129 Turin, Italy.ORCID 0000-0003-0875-6913
Domiziana RinaldiDepartment of Neuroscience, Mental Health and Sense Organs (NESMOS), Sapienza University of Rome, 00189 Rome, Italy.
Carlo Alberto ArtusiDepartment of Neuroscience "Rita Levi Montalcini", University of Turin, 10126 Torino, Italy.ORCID 0000-0001-8579-3772
Gabriele ImbalzanoDepartment of Neuroscience "Rita Levi Montalcini", University of Turin, 10126 Torino, Italy.
Martina PateraDepartment of Human Neurosciences, Sapienza University of Rome, 00185 Rome, Italy.
Leonardo LopianoDepartment of Neuroscience "Rita Levi Montalcini", University of Turin, 10126 Torino, Italy.
Francesco PontieriDepartment of Neuroscience, Mental Health and Sense Organs (NESMOS), Sapienza University of Rome, 00189 Rome, Italy.
Gabriella OlmoData Analytics and Technologies for Health Lab (ANTHEA), Department of Control and Computer Engineering, Politecnico di Torino, 10129 Turin, Italy.
Antonio SuppaDepartment of Human Neurosciences, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-9903-5550

Funding

European Union under the Italian National Re-434 covery and Resilience Plan (NRRP) of NextGenerationEU PE00000001
6 · The paper itself

Abstract

backgroundDyskinesias and freezing of gait are episodic disorders in Parkinson's disease, characterized by a fluctuating and unpredictable nature. This cross-sectional study aims to objectively monitor Parkinsonian patients experiencing dyskinesias and/or freezing of gait during activities of daily living and assess possible changes in spatiotemporal gait parameters.

methodsSeventy-one patients with Parkinson's disease (40 with dyskinesias and 33 with freezing of gait) were continuously monitored at home for a minimum of 5 days using a single wearable sensor. Dedicated machine-learning algorithms were used to categorize patients based on the occurrence of dyskinesias and freezing of gait. Additionally, specific spatiotemporal gait parameters were compared among patients with and without dyskinesias and/or freezing of gait.

resultsThe wearable sensor algorithms accurately classified patients with and without dyskinesias as well as those with and without freezing of gait based on the recorded dyskinesias and freezing of gait episodes. Standard spatiotemporal gait parameters did not differ significantly between patients with and without dyskinesias or freezing of gait. Both the time spent with dyskinesias and the number of freezing of gait episodes positively correlated with the disease severity and medication dosage.

conclusionsA single inertial wearable sensor shows promise in monitoring complex, episodic movement patterns, such as dyskinesias and freezing of gait, during daily activities. This approach may help implement targeted therapeutic and preventive strategies for Parkinson's disease.

Indexed as

dyskinesiasfreezing of gaitlong-term monitoringParkinson’s diseasewearable sensors

Identifiers

PMID38790307
PMCPMC11117481

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.