Evidence map›Paper›PMID 38790226›Full record

ArticleGenes2024

Interleukin-1β Polymorphisms Are Genetic Markers of Susceptibility to Periprosthetic Joint Infection in Total Hip and Knee Arthroplasty.

Valentina Granata, Dario Strina, Valentina Possetti, Roberto Leone, Sonia Valentino, Katia Chiappetta, Mattia Loppini, Alberto Mantovani, Barbara Bottazzi, Rosanna Asselta and 2 more

Abstract read
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Valentina GranataIRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.ORCID 0000-0003-1560-378X
Dario StrinaIRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.
Valentina PossettiIRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.ORCID 0000-0002-2220-2944
Roberto LeoneIRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.
Sonia ValentinoIRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.
Katia ChiappettaIRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.
Mattia LoppiniIRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.ORCID 0000-0001-8569-0669
Alberto MantovaniIRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.
Barbara BottazziIRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.ORCID 0000-0002-1930-9257
Rosanna AsseltaIRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.ORCID 0000-0001-5351-0619
Cristina SobacchiIRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.ORCID 0000-0002-2684-7184
Antonio InforzatoIRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.ORCID 0000-0001-8110-0027

Funding

Fondazione Beppe e Nuccy Angiolini ONLUS na
6 · The paper itself

Abstract

Periprosthetic joint infections (PJIs) are serious complications of prosthetic surgery. The criteria for the diagnosis of PJI integrate clinical and laboratory findings in a complex and sometimes inconclusive workflow. Host immune factors hold potential as diagnostic biomarkers in bone and joint infections. We reported that the humoral pattern-recognition molecule long pentraxin 3 (PTX3) predicts PJI in total hip and knee arthroplasty (THA and TKA, respectively). If and how genetic variation in

Indexed as

Arthroplasty, Replacement, HipArthroplasty, Replacement, KneeGenetic Predisposition to DiseaseInterleukin-1betaPolymorphism, Single NucleotideProsthesis-Related InfectionsAgedCase-Control StudiesC-Reactive ProteinFemaleGenetic MarkersHumansMaleMiddle AgedPentraxinsSerum Amyloid P-ComponentC-Reactive ProteinGenetic MarkersIL1B protein, humanInterleukin-1betaPentraxinsSerum Amyloid P-Componentassociation analysisbiomarkerepistasishaplotypeperiprosthetic infectionPTX3single-nucleotide polymorphism

Identifiers

PMID38790226
PMCPMC11120921

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.