Evidence map›Paper›PMID 38790037›Full record

ArticleJournal of nanobiotechnology2024

Short cell-penetration peptide conjugated bioreducible polymer enhances gene editing of CRISPR system.

Xiaobo Wang, Chengyuan Cai, Weiqi Lv, Kechen Chen, Jiaxin Li, Kaitong Liao, Yanqun Zhang, Hongxin Huang, Ying Lin, Zhili Rong and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Recent Advances and Future Prospects in Biological-Membrane-Targeted Polymers.Polymer science & technology (Washington, D.C.) · 2025
    Review
  3. Review
  4. Article
  5. Expanding the CRISPR/Cas toolkit: applications in proteomics and theranostics.Frontiers in bioengineering and biotechnology · 2025
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiaobo Wang *Dermatology Hospital, Southern Medical University, Guangzhou, 510091, China.
Chengyuan Cai *Cancer Research Institute, School of Basic Medical Sciences, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), Southern Medical University, Guangzhou, 510515, China.
Weiqi LvDermatology Hospital, Southern Medical University, Guangzhou, 510091, China.
Kechen ChenCancer Research Institute, School of Basic Medical Sciences, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), Southern Medical University, Guangzhou, 510515, China.
Jiaxin LiCancer Research Institute, School of Basic Medical Sciences, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), Southern Medical University, Guangzhou, 510515, China.
Kaitong LiaoCancer Research Institute, School of Basic Medical Sciences, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), Southern Medical University, Guangzhou, 510515, China.
Yanqun ZhangCancer Research Institute, School of Basic Medical Sciences, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), Southern Medical University, Guangzhou, 510515, China.
Hongxin HuangDermatology Hospital, Southern Medical University, Guangzhou, 510091, China.
Ying LinCancer Research Institute, School of Basic Medical Sciences, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), Southern Medical University, Guangzhou, 510515, China.
Zhili RongDermatology Hospital, Southern Medical University, Guangzhou, 510091, China. rongzhili@smu.edu.cn.
Xiaopin DuanCancer Research Institute, School of Basic Medical Sciences, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Key Laboratory of Organ Failure Research (Ministry of Education), Southern Medical University, Guangzhou, 510515, China. xpduan@smu.edu.cn.

Funding

China Postdoctoral Science Foundation 2022M721492Guangdong Basic and Applied Basic Research Foundation 2022A1515011091Guangdong Basic and Applied Basic Research Foundation 2023A1515012269National Key Research and Development Program of China 2022YFA0806303National Natural Science Foundation of China 82070002National Natural Science Foundation of China 82072329National Natural Science Foundation of China 82303995National Natural Science Foundation of China 82370078National Natural Science Foundation of China 82372118
6 · The paper itself

Abstract

CRISPR-based gene therapy offers precise targeting and specific editing of disease-related gene sequences, potentially yielding long-lasting treatment effects. However, efficient delivery remains a significant challenge for its widespread application. In this study, we design a novel short peptide-conjugated bioreducible polymer named TSP

Indexed as

Cell-Penetrating PeptidesCRISPR-Cas SystemsGene EditingPlasmidsAnimalsGenetic TherapyHEK293 CellsHumansMicePolymersCell-Penetrating PeptidesPolymersBioreducible polymerCRISPR systemGenome editingShort cell-penetration peptideTranscriptional activation

Identifiers

PMID38790037
PMCPMC11127455

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.