Evidence map›Paper›PMID 38789968›Full record

Trial reportBMC anesthesiology2024

Effects of esketamine on postoperative fatigue syndrome in patients after laparoscopic resection of gastric carcinoma: a randomized controlled trial.

Xinru Lin, Xiaoxue Feng, Linxiao Sun, Yijian Wang, Xudong Wu, Shufang Lu, Lulu Shao, Wenchao Wang, Liqun Yang, Wujun Geng and 1 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07131033 (Effects of Perioperative Intravenous Infusion Esketamine Combined With Magnesium Sulfate for Postoperative Fatigue Syndrome in Patients Undergoing Laparoscopic Cholecystectomy), which is not on this map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07131033 phase1 / phase2completednot on this mapstarted 2025, after this paper: background citation

Effects of Perioperative Intravenous Infusion Esketamine Combined With Magnesium Sulfate for Postoperative Fatigue Syndrome in Patients Undergoing Laparoscopic Cholecystectomy: A 2×2 Factorial Randomized Controlled Trial

TypeinterventionalSponsorThe Second People's Hospital of Huai'anRan2025 to 2026Enrolled120ConditionsLaparoscopic Cholecystectomy, Alleviate Postoperative Fatigue SyndromeArmsEsketamine, Magnesium sulfate, Esketamine and Magnesium sulfate, Saline
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xinru LinDepartment of Pain, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Xiaoxue FengDepartment of Pain, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Linxiao SunKey Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, 325000, China.
Yijian WangDepartment of Pain, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Xudong WuDepartment of Pain, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Shufang LuDepartment of Pain, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Lulu ShaoDepartment of Pain, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Wenchao WangDepartment of Pain, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Liqun Yang *Department of Anesthesiology Renji Hospital, Shanghai Jiaotong University School of Medicine, No.160 Pujian road, Shanghai, 200127, China. lqyang72721@126.com.
Wujun Geng *Department of Pain, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China. gengwujun@wzhospital.cn.
Hai Lin *Department of Pain, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China. 422133061@qq.com.

Funding

National Natural Science Foundation of China 81973620the Medical Newcomer Project of Zhejiang Province Zhewei Ban [2020] No. 18-9
6 · The paper itself

Abstract

backgroundDespite the implementation of various postoperative management strategies, the prevalence of postoperative fatigue syndrome (POFS) remains considerable among individuals undergoing laparoscopic radical gastrectomy. While the N-methyl-D-aspartic acid receptor antagonist esketamine has demonstrated efficacy in enhancing sleep quality and alleviating postoperative pain, its impact on POFS remains uncertain. Consequently, the objective of this study is to ascertain whether perioperative administration of esketamine can effectively mitigate the occurrence of POFS in patients undergoing laparoscopic radical gastrectomy.

methodsA total of 133 patients diagnosed with gastric cancer were randomly assigned to two groups, namely the control group (Group C) (n = 66) and the esketamine group (Group E) (n = 67), using a double-blind method. The Group C received standardized anesthesia, while the Group E received esketamine in addition to the standardized anesthesia. The primary outcome measure assessed was the Christensen fatigue score at 3 days after the surgical procedure, while the secondary outcomes included the disparities in postoperative fatigue, postoperative pain, sleep quality, and adverse reactions between the two groups.

resultsIn the group receiving esketamine, the fatigue scores of Christensen on the third day after surgery were significantly lower compared to the Group C (estimated difference, -0.70; 95% CI, -1.37 to -0.03; P = 0.040). Additionally, there was a significant decrease in the occurrence of fatigue in the Group E compared to the Group C on the first and third days following surgery (P < 0.05). Also, compared to individuals who had distal gastrectomy, those who had entire gastrectomy demonstrated a higher degree of postoperative tiredness reduction with esketamine. Furthermore, the Group E exhibited reduced postoperative pain and improved sleep in comparison to the Group C. Both groups experienced similar rates of adverse events.

conclusionsThe use of esketamine during the perioperative period can improve POFS after laparoscopic radical gastrectomy, without adverse reactions.

trial registrationRegistered in the Chinese Clinical Trial Registry (ChiCTR2300072167) on 05/06 /2023.

Indexed as

GastrectomyKetamineLaparoscopyPostoperative ComplicationsPostoperative PainStomach NeoplasmsAgedDouble-Blind MethodFatigueFemaleHumansMaleMiddle AgedEsketamineKetamineEsketamineGastric carcinomaPostoperative fatigue syndromeRandomized controlled trial

Identifiers

PMID38789968
PMCPMC11127346

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.