ArticleNature metabolism2024
Weak neuronal glycolysis sustains cognition and organismal fitness.
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Article in Nature metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Disentangling the inverse relationship between cancer and Alzheimer's or Parkinson's disease: A systematic review on Mendelian randomization studies.Neurobiology of disease · 2025Pooled it
- Resetting the glucose sensor: dorzagliatin and the evolution of glucokinase activation in diabetes therapy.BMJ open diabetes research & care · 2026Review
- Fungal-Derived Decahydrofluorene Alkaloids Promote Mitochondrial Resilience and Neuroprotection in Cellular and Animal Models of Parkinson's Disease.Antioxidants (Basel, Switzerland) · 2026Article
- Histone H4 lysine 12 lactylation-driven ZIP14 expression is involved in electroacupuncture therapy against cerebral ischemia/reperfusion injury in mice.Journal of advanced research · 2026Article
- Brain mitochondria as key drivers of cognition and behaviour.Nature reviews. Neuroscience · 2026Review
- Transaldolase 1 contributes to pentose phosphate pathway disruption and synaptic dysfunction in Alzheimer's disease.Translational neurodegeneration · 2026Article
- Metabolic crosstalk in the ageing brain: astrocyte-neuron coupling as a target for homeostatic restoration and therapy.Translational neurodegeneration · 2026Review
- Monocarboxylate transporter 2 regulates maintenance of myelin and axonal integrity by oligodendrocytes.Nature communications · 2026Article
- From brain bioenergetics to hypothalamic glucoregulation: A shared-systems hypothesis for intrinsic dysglycemia in schizophrenia.Reviews in endocrine & metabolic disorders · 2026Review
- Dysfunction of the CD38-Miro1 Axis Disrupts Astrocyte-neuron Mitochondrial Transfer in Alzheimer's Disease: Mechanisms and Therapeutic Restoration.Journal of molecular neuroscience : MN · 2026Review
- Diet, Metabolism and Synaptic Function: Integrating Evidence Across Models in Neurodegeneration Research.Biomedicines · 2026Review
- Pentose Phosphate Pathway Is Critical for Providing Energy by Bypassing 6-Phosphofructo-1-Kinase (PFK1) During Increased Neuronal Activity.Metabolites · 2026Review
- Ketone bodies mitigate against systemic inflammation-induced changes in brain energy metabolism and delirium-like deficits in aged mice.bioRxiv : the preprint server for biology · 2026Article
- Distinct signaling mechanisms and proteome phenotypes are elicited by compartment-specific genetic defects of copper homeostasis.bioRxiv : the preprint server for biology · 2026Article
- Anesthesia, perimortem conditions, and brain harvest method govern the measured metabolome: analysis of substandard samples generates flawed metabolite levels.Oxford open neuroscience · 2026Article
- Metabolic interactions in the brain: the crucial roles of neurons, astrocytes, and microglia in health and disease.Frontiers in neuroscience · 2026Review
- Ershiwuwei Shanhu Pill ameliorates cognitive impairment in Alzheimer's disease mice by remodeling gut microbiota and host serum metabolites.Frontiers in aging neuroscience · 2026Article
- Mitochondrial membrane junction-mediated ATP channeling drives activity-dependent glucose metabolism.bioRxiv : the preprint server for biology · 2025Article
- Cellular Distribution of Pyruvate Kinase M2 After Spinal Cord Injury in Adult Rats.Molecular neurobiology · 2025Article
- Metabolic reprogramming in ischemic stroke: when glycolytic overdrive meets lipid storm.Cell death & disease · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Daniel Jimenez-BlascoInstitute of Functional Biology and Genomics, Universidad de Salamanca, CSIC, Salamanca, Spain.ORCID http://orcid.org/0000-0002-1384-1832
Jesús AgullaInstitute of Functional Biology and Genomics, Universidad de Salamanca, CSIC, Salamanca, Spain.ORCID http://orcid.org/0000-0001-9574-2549
Rebeca LapresaInstitute of Functional Biology and Genomics, Universidad de Salamanca, CSIC, Salamanca, Spain.ORCID http://orcid.org/0000-0001-8901-3972
Marina Garcia-MaciaInstitute of Functional Biology and Genomics, Universidad de Salamanca, CSIC, Salamanca, Spain.ORCID http://orcid.org/0000-0002-3908-9060
Veronica Bobo-JimenezInstitute of Functional Biology and Genomics, Universidad de Salamanca, CSIC, Salamanca, Spain.
Dario Garcia-RodriguezInstitute of Functional Biology and Genomics, Universidad de Salamanca, CSIC, Salamanca, Spain.ORCID http://orcid.org/0000-0001-5416-130X
Israel Manjarres-RazaInstitute of Functional Biology and Genomics, Universidad de Salamanca, CSIC, Salamanca, Spain.ORCID http://orcid.org/0000-0001-6314-9839
Emilio FernandezInstitute of Functional Biology and Genomics, Universidad de Salamanca, CSIC, Salamanca, Spain.
Yannick JeansonRESTORE, University of Toulouse, Inserm U1031, CNRS 5070, UPS, EFS, Toulouse, France.ORCID http://orcid.org/0000-0001-5325-3130
Spiro KhouryRESTORE, University of Toulouse, Inserm U1031, CNRS 5070, UPS, EFS, Toulouse, France.ORCID http://orcid.org/0000-0003-0365-7406
Jean-Charles PortaisRESTORE, University of Toulouse, Inserm U1031, CNRS 5070, UPS, EFS, Toulouse, France.
Daniel PadroCIC biomaGUNE, Basque Research and Technology Alliance, Donostia-San Sebastián, Spain.
Pedro Ramos-CabrerCIC biomaGUNE, Basque Research and Technology Alliance, Donostia-San Sebastián, Spain.ORCID http://orcid.org/0000-0003-0368-7031
Peter CarmelietLaboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, VIB, Leuven, Belgium.ORCID http://orcid.org/0000-0001-7961-1821
Angeles AlmeidaInstitute of Functional Biology and Genomics, Universidad de Salamanca, CSIC, Salamanca, Spain.ORCID http://orcid.org/0000-0003-0485-8904
Juan P BolañosInstitute of Functional Biology and Genomics, Universidad de Salamanca, CSIC, Salamanca, Spain. jbolanos@usal.es.ORCID http://orcid.org/0000-0002-3949-6862
Funding
No grant is acknowledged in the PubMed record.
Abstract
The energy cost of neuronal activity is mainly sustained by glucose
Indexed as
CognitionGlycolysisNeuronsPhosphofructokinase-2AnimalsEnergy MetabolismGlucoseMiceMitochondriaNADGlucoseNADPFKFB3 protein, mousePhosphofructokinase-2
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.