Article in Archives of toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
13 authors.
Eliska PrchalovaUniversity of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03, Hradec Kralove, Czech Republic.ORCID 0000-0003-0227-0007
Rudolf AndrysUniversity of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03, Hradec Kralove, Czech Republic.ORCID 0000-0003-1108-3924
Jaroslav PejchalUniversity of Defence, Military Faculty of Medicine, Department of Toxicology and Military Pharmacy, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic.ORCID 0000-0003-2228-7922
Zuzana KohoutovaUniversity of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03, Hradec Kralove, Czech Republic.ORCID 0000-0003-3382-3997
Karolina KnittelovaUniversity of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03, Hradec Kralove, Czech Republic.ORCID 0000-0002-5187-8986
Tereza HofmanovaUniversity of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03, Hradec Kralove, Czech Republic.ORCID 0000-0001-8453-4023
Adam SkarkaUniversity of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03, Hradec Kralove, Czech Republic.ORCID 0000-0002-7355-6857
Alzbeta DlabkovaUniversity of Defence, Military Faculty of Medicine, Department of Toxicology and Military Pharmacy, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic.ORCID 0000-0001-8929-2262
Miroslav PsotkaUniversity of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03, Hradec Kralove, Czech Republic.ORCID 0000-0002-7857-7411
Lukas PrchalUniversity Hospital in Hradec Kralove, Biomedical Research Center, Sokolska 581, 500 05, Hradec Kralove, Czech Republic.ORCID 0000-0001-9698-4478
Kamil MusilekUniversity of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03, Hradec Kralove, Czech Republic.ORCID 0000-0002-7504-4062
Jana Zdarova KarasovaUniversity of Defence, Military Faculty of Medicine, Department of Toxicology and Military Pharmacy, Trebesska 1575, 500 01, Hradec Kralove, Czech Republic. zdarovakarasovaj@unob.cz.ORCID 0000-0003-0891-9591
David MalinakUniversity of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03, Hradec Kralove, Czech Republic. david.malinak@uhk.cz.ORCID 0000-0002-0665-0667
Funding
Grantová Agentura České Republiky GA21-03000SUniverzita Hradec Králové SV2112-2023
6 · The paper itself
Abstract
Six novel brominated bis-pyridinium oximes were designed and synthesized to increase their nucleophilicity and reactivation ability of phosphorylated acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Their pK
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents. · full record | OpenQuestion