Evidence map›Paper›PMID 38789656›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2024

Rose geranium in sesame oil nasal spray to improve nasal vestibulitis symptoms: a randomized controlled trial.

Elizabeth J Cathcart-Rake, Kimberly Steinert, Deanne Smith, Susan Lewis-Peters, Karthik Giridhar, Paul Novotny, Darcie Dauer, Amanda O'Connor, Stephan Thomé, Marsha K Erickson and 2 more

Registry-linked trialAbstract readRandomized Controlled TrialClinical Trial, Phase IIIComparative Study
PubMed Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04620369 (Rose Geranium in Sesame Oil Nasal Spray as an Agent to Improve Symptoms of Nasal Vestibulitis), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04620369 phase3completednot on this map

Rose Geranium in Sesame Oil Nasal Spray as an Agent to Improve Symptoms of Nasal Vestibulitis: A Phase III Double Blinded Randomized Controlled Trial

TypeinterventionalSponsorMayo ClinicRan2020 to 2022Enrolled106ConditionsHematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm, Nasal VestibulitisArmsPlacebo Administration, Questionnaire Administration, Rose Geranium in Sesame Oil Nasal Spray
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Elizabeth J Cathcart-RakeDepartment of Medical Oncology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA. Cathcart-Rake.Elizabeth@mayo.edu.
Kimberly SteinertDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Deanne SmithDepartment of Medical Oncology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
Susan Lewis-PetersDepartment of Medical Oncology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
Karthik GiridharDepartment of Medical Oncology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
Paul NovotnyDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Darcie DauerEssentia Health Community Cancer Research Program, 523 North Third Street, Brainerd, MN, USA.
Amanda O'ConnorDepartment of Medical Oncology, Mayo Clinic - Mankato, Mankato, MN, USA.
Stephan ThoméDepartment of Medical Oncology, Mayo Clinic - Mankato, Mankato, MN, USA.
Marsha K EricksonEssentia Health Cancer Center, 420 East First St, Duluth, MN, USA.
Bret B FridayEssentia Health Cancer Center, 420 East First St, Duluth, MN, USA.
Charles L LoprinziDepartment of Medical Oncology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of this phase III randomized double-blinded controlled trial was to investigate the efficacy of a rose geranium in sesame oil (RG) nasal spray compared with an isotonic saline (IS) nasal spray for alleviating nasal vestibulitis symptoms among patients undergoing chemotherapy.

methodsPatients undergoing active chemotherapy who reported associated nasal symptoms were randomized 1:1 to receive RG or IS, administered twice daily for 2 weeks. Consenting participants completed nasal symptom questionnaires at baseline and then weekly while on treatment. The proportion of patients experiencing improvements in their nasal symptoms 2 weeks after initiating the nasal spray, using a six-point global impression of change score, was estimated within and between each randomized arm, and compared between arms, using Fisher's exact test. The estimated odds ratio was determined (95% confidence interval).

resultsOne hundred and six patients consented to this study; 43 participants in the RG arm and 41 in the IS arm were evaluable for the primary endpoint. Participants had a mean age of 57.8 years (SD 13.9). Demographic characteristics and baseline nasal symptoms were similar between arms. Of the evaluable participants who received RG, 67.4% reported improved nasal symptoms, compared with 36.6% of the participants who received IS (P = 0.009). Adverse events were sparse and did not differ between arms.

conclusionRose geranium in sesame oil significantly improves nasal vestibulitis symptoms among patients undergoing chemotherapy.

trial registrationNCT04620369.

Indexed as

Nasal SpraysSesame OilAdultAgedAntineoplastic AgentsDouble-Blind MethodFemaleGeraniumHumansMaleMiddle AgedSurveys and QuestionnairesTreatment OutcomeAntineoplastic AgentsNasal SpraysSesame OilIsotonic salineRose geraniumSesame oil

Identifiers

PMID38789656

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.