Evidence map›Paper›PMID 38789633›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2024

The effects of ecdysterone and enalapril on nitric oxide synthesis and the markers of oxidative stress in streptozotocin-induced diabetes in rats: a comparative study.

Olga Akopova, Yulia Korkach, Vadim Sagach

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Olga AkopovaStem cell laboratory, Bogomoletz Institute of Physiology, NAS of Ukraine, Kiev, Ukraine. o.v.akopova01@gmail.com.
Yulia KorkachCirculation department, Bogomoletz Institute of Physiology, NAS of Ukraine, Kiev, Ukraine.
Vadim SagachCirculation department, Bogomoletz Institute of Physiology, NAS of Ukraine, Kiev, Ukraine.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular functions in diabetes greatly depend on constitutive NOS (cNOS) activity. A comparative study of the effects of a steroid hormone ecdysterone and enalapril, an ACE inhibitor widely used to treat cardiac disorders on cNOS, inducible NOS (iNOS), xanthine oxidoreductase (XOR) activity, RNS, ROS, and lipid peroxidation in heart tissue in experimental diabetes was conducted. The rat model of diabetes was established by streptozotocin injection. NOS activity, NO

Indexed as

Angiotensin-Converting Enzyme InhibitorsDiabetes Mellitus, ExperimentalEcdysteroneEnalaprilNitric OxideOxidative StressRats, WistarAnimalsBiomarkersLipid PeroxidationMaleMyocardiumNitric Oxide Synthase Type IIRatsReactive Nitrogen SpeciesReactive Oxygen SpeciesAngiotensin-Converting Enzyme InhibitorsBiomarkersEcdysteroneEnalaprilNitric OxideNitric Oxide Synthase Type IINos2 protein, ratReactive Nitrogen SpeciesReactive Oxygen SpeciesStreptozocinEcdysteroneHeartNOSOxidative stressSTZ-induced diabetesXanthine oxidase

Identifiers

PMID38789633

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.