ArticleScientific reports2024
Gut microbiota promoting propionic acid production accompanies caloric restriction-induced intentional weight loss in cats.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed.
- DietaryAnimals : an open access journal from MDPI · 2026Article
- Causal relationship between dietary habits and low hand grip strength: A Mendelian randomization study.Medicine · 2026Article
- PasteurizedMicrobiology spectrum · 2026Article
- Effect of Dietary Postbiotics Derived fromVeterinary sciences · 2026Article
- Variations in the Gut Microbiota of Stray and Domestic Cats.Animals : an open access journal from MDPI · 2026Article
- Exploring the impact of rumen microbiome on ovine flavor-related compounds and comparing flavor profiles between Tibetan sheep and Small-tail Han sheep.BMC microbiology · 2026Article
- Serum metabolomics identifies metabolic changes in obese cats fed enzymatically hydrolyzed poultry byproduct meal.Journal of veterinary internal medicine · 2026Article
- Synergistic activity of synbiotic blend between3 Biotech · 2025Article
- Functional Insights Into the Effect of Feralisation on the Gut Microbiota of Cats Worldwide.Molecular ecology · 2025Article
- Fecal bile acid dysmetabolism and reduced ursodeoxycholic acid correlate with novel microbial signatures in feline chronic kidney disease.Frontiers in microbiology · 2024Article
- Untargeted Metabolic Profiling of Cat Urine and Plasma in Hypertension.Journal of veterinary internal medicineArticle
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Abstract
Rodent models and human clinical studies have shown gut microbiota-derived short-chain fatty acids (SCFAs) play roles in obesity and insulin resistance. These roles have been minimally explored in cats, where in the USA an estimated 60% of cats are overweight or obese. Overweight/obese research cats (n = 7) were transitioned from a maintenance diet to a reduced calorie diet fed ad libitum for 7 days, then calories were restricted to achieve 1-2% weight loss per week for an additional 77 days. Cats then received their original maintenance diet again for 14 days. Significant intentional weight loss was noted after calorie restriction (adjusted p < 0.0001). 16S rRNA gene amplicon sequencing and targeted SCFA metabolomics were performed on fecal samples. Fecal microbial community structure significantly differed between the four study phases (PERMANOVA p = 0.011). Fecal propionic acid was significantly higher during caloric restriction-induced weight loss (adjusted p < 0.05). Repeated measures correlation revealed the relative abundances of Prevotella 9 copri (correlation coefficient = 0.532, 95% CI (0.275, 0.717), p = 0.0002) significantly correlated with propionic acid composition. Like humans, obese cats experienced an altered microbial community structure and function, favoring propionic acid production, during caloric restriction-induced weight loss.
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