ArticleNature communications2024
Phosphorus deficiency alleviates iron limitation in Synechocystis cyanobacteria through direct PhoB-mediated gene regulation.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Article
- A Comment on "Deep Proteogenomics of a Photosynthetic Cyanobacterium".Journal of proteome research · 2026Article
- Integrated mineralogical, metabolomic, and gene expression analysis of the phosphate-solubilizing mechanism of Pseudomonas sp. PSB-13.World journal of microbiology & biotechnology · 2026Article
- Review
- Aluminum Alleviation of Iron Deficiency Chlorosis Is Conserved in Wild Rice RelativePlants (Basel, Switzerland) · 2026Article
- Community Structure, Growth-Promoting Potential, and Genomic Analysis of Seed-Endophytic Bacteria inMicroorganisms · 2025Article
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Authors and funding
10 authors.
Funding
Abstract
Iron and phosphorus are essential nutrients that exist at low concentrations in surface waters and may be co-limiting resources for phytoplankton growth. Here, we show that phosphorus deficiency increases the growth of iron-limited cyanobacteria (Synechocystis sp. PCC 6803) through a PhoB-mediated regulatory network. We find that PhoB, in addition to its well-recognized role in controlling phosphate homeostasis, also regulates key metabolic processes crucial for iron-limited cyanobacteria, including ROS detoxification and iron uptake. Transcript abundances of PhoB-targeted genes are enriched in samples from phosphorus-depleted seawater, and a conserved PhoB-binding site is widely present in the promoters of the target genes, suggesting that the PhoB-mediated regulation may be highly conserved. Our findings provide molecular insights into the responses of cyanobacteria to simultaneous iron/phosphorus nutrient limitation.
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Registered trials
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