Evidence map›Paper›PMID 38789304›Full record

ArticleUltrasound in medicine & biology2024

Neuronavigation-Guided Transcranial Histotripsy (NaviTH) System.

Sang Won Choi, Mahmoud Komaiha, Dave Choi, Ning Lu, Tyler I Gerhardson, Adam Fox, Neeraj Chaudhary, Sandra Camelo-Piragua, Timothy L Hall, Aditya S Pandey and 2 more

Abstract read
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In one paragraph

Article in Ultrasound in medicine & biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Focused ultrasound for brain metastases.Neuro-oncology advances · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025
    Review
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sang Won ChoiDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Mahmoud KomaihaDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Dave ChoiDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Ning LuDepartment of Biomedical Engineering, Stanford University, Stanford, CA, USA.
Tyler I GerhardsonDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Adam FoxDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA; Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Neeraj ChaudharyDepartment of Radiology, University of Michigan, Ann Arbor, MI, USA.
Sandra Camelo-PiraguaDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.
Timothy L HallDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Aditya S PandeyDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Zhen XuDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Jonathan R SukovichDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. Electronic address: jsukes@umich.edu.

Funding

Novel Ultrasonic Technique for the Treatment of Hemorrhagic StrokeR01NS108042 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PANDEY, ADITYA S · 2018 to 2022
$2.6M
Transcranial Magnetic Resonance guided Histotripsy (tcMRgHt)R01EB028309 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XU, ZHEN · 2019 to 2022
$2.4M
Acoustic Cavitation Emission (ACE) Feedback Methods for Monitoring Histotripsy-Induced Tissue Fractionation In SituR01EB032772 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SUKOVICH, JONATHAN ROBERT · 2022 to 2025
$2.0M
Human Intracerebral Hemorrhage: Impact of Hematoma Size, Hemolysis and Iron Overload on Edema and White Matter Survival by MRIR01NS131514 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHAUDHARY, NEERAJ, PANDEY, ADITYA S · 2024 to 2025
$741k
NIBIB NIH HHS R01 EB028309NIBIB NIH HHS R01 EB032772NINDS NIH HHS R01 NS108042NINDS NIH HHS R01 NS131514
6 · The paper itself

Abstract

objectiveThe goal of the work described here was to develop the first neuronavigation-guided transcranial histotripsy (NaviTH) system and associated workflow for transcranial ablation.

methodsThe NaviTH system consists of a 360-element, 700 kHz transmitter-receiver-capable transcranial histotripsy array, a clinical neuronavigation system and associated equipment for patient-to-array co-registration and therapy planning and targeting software systems. A workflow for NaviTH treatments, including pre-treatment aberration correction, was developed. Targeting errors stemming from target registration errors (TREs) during the patient-to-array co-registration process, as well as focal shifts caused by skull-induced aberrations, were investigated and characterized. The NaviTH system was used in treatments of two <96 h post-mortem human cadavers and in experiments in two excised human skullcaps.

resultsThe NaviTH was successfully used to create ablations in the cadaver brains as confirmed in post-treatment magnetic resonance imaging A total of three ablations were created in the cadaver brains, and targeting errors of 9, 3.4 and 4.4 mm were observed in corpus callosum, septum and thalamus targets, respectively. Errors were found to be caused primarily by TREs resulting from transducer tracking instrument design flaws and imperfections in the treatment workflow. Transducer tracking instrument design and workflow improvements reduced TREs to <2 mm, and skull-induced focal shifts, following pre-treatment aberration correction, were 0.3 mm. Total targeting errors of the NaviTH system following the noted improvements were 2.5 mm.

conclusionsThe feasibility of using the first NaviTH system in a human cadaver model has been determined. Although accuracy still needs to be improved, the proposed system has the potential to allow for transcranial histotripsy therapies without requiring active magnetic resonance treatment guidance.

Indexed as

CadaverNeuronavigationBrainEquipment DesignHigh-Intensity Focused Ultrasound AblationHumansBrainHistotripsyNeuronavigation guidanceTranscranial

Identifiers

PMID38789304
PMCPMC11822949

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.