Evidence map›Paper›PMID 38788885›Full record

ArticleClinical immunology (Orlando, Fla.)2024

IL-27 promotes pathogenic T cells in a mouse model of Sjögren's disease.

Ivy L Debreceni, Jennifer Y Barr, Ellen M Upton, Yi-Guang Chen, Scott M Lieberman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical immunology (Orlando, Fla.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ivy L DebreceniInterdisciplinary Graduate Program in Immunology, Carver College of Medicine, University of Iowa, 500 Newton Road, 2191 Medical Laboratories, Iowa City, IA 52242, USA; Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, 500 Newton Road, 2191 Medical Laboratories, Iowa City, IA 52242, USA. Electronic address: Ivy-gandy@uiowa.edu.
Jennifer Y BarrScientific Editing and Research Communication Core, Carver College of Medicine, University of Iowa, 451 Newton Road, 130 Medicine Administration Building, Iowa City, IA 52242, USA. Electronic address: Jennifer-barr@uiowa.edu.
Ellen M UptonInterdisciplinary Graduate Program in Immunology, Carver College of Medicine, University of Iowa, 500 Newton Road, 2191 Medical Laboratories, Iowa City, IA 52242, USA; Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, 451 Newton Road, 200 Medicine Administration Building, Iowa City, IA 52242, USA. Electronic address: Ellen-upton@uiowa.edu.
Yi-Guang ChenDepartment of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. Electronic address: yichen@mcw.edu.
Scott M LiebermanInterdisciplinary Graduate Program in Immunology, Carver College of Medicine, University of Iowa, 500 Newton Road, 2191 Medical Laboratories, Iowa City, IA 52242, USA; Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, 500 Newton Road, 2191 Medical Laboratories, Iowa City, IA 52242, USA. Electronic address: Scott-lieberman@uiowa.edu.

Funding

PREDOCTORAL TRAINING PROGRAM IN IMMUNOLOGYT32AI007485 · NIAID · UNIVERSITY OF IOWA · PI Kevin L Legge · 1995 to 2026
$5.4M
Cytokines driving T cell dysregulation in lacrimal gland autoimmunityR01EY027731 · NEI · UNIVERSITY OF IOWA · PI LIEBERMAN, SCOTT MATTHEW · 2018 to 2022
$2.4M
Type I interferon dependent and independent roles of IL-27 in Sjogren'sF31EY035130 · NEI · UNIVERSITY OF IOWA · PI DEBRECENI, IVY LYNNE · 2023 to 2023
$35k
NEI NIH HHS F31 EY035130NEI NIH HHS R01 EY027731NIAID NIH HHS T32 AI007485
6 · The paper itself

Abstract

Sjögren's disease (SjD) is a chronic autoimmune disease characterized by focal lymphocytic inflammation in lacrimal and salivary glands. We recently identified IL-27 as a requisite signal for the spontaneous SjD-like manifestations in nonobese diabetic (NOD) mice. Here, we define T cell-intrinsic effects of IL-27 in lacrimal gland disease in NOD mice. IL-27 receptor was required by both CD4 T effector (Te) cells and CD8 T cells to mediate focal inflammation. Intrinsic IL-27 signaling was associated with PD-1 and ICOS expressing T follicular helper (Tfh)-like CD4 Te cells within lacrimal glands, including subsets defined by CD73 or CD39 expression. CD8 T cells capable of IL-27 signaling also expressed PD-1 with subsets expressing ICOS and CD73 demonstrating a T follicular cytotoxic (Tfc)-like cell phenotype and others expressing a CD39

Indexed as

CD8-Positive T-LymphocytesDisease Models, AnimalLacrimal ApparatusMice, Inbred NODSjogren's SyndromeAnimalsApyraseCD4-Positive T-LymphocytesFemaleInducible T-Cell Co-Stimulator ProteinInterleukin-27InterleukinsMiceProgrammed Cell Death 1 ReceptorReceptors, InterleukinSignal TransductionApyraseIl27 protein, mouseIl27ra protein, mouseInducible T-Cell Co-Stimulator ProteinInterleukin-27InterleukinsPdcd1 protein, mouseProgrammed Cell Death 1 ReceptorReceptors, InterleukinExhausted CD8 T cellsIL-27Sjögren's diseaseT follicular cytotoxic cellsT follicular helper cellsT peripheral helper cells

Identifiers

PMID38788885
PMCPMC11203157

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.