ArticleCancer cell2024
Olfactory neuroblastoma mimics molecular heterogeneity and lineage trajectories of small-cell lung cancer.
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Article in Cancer cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
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Who cites it
30 citing papers in PubMed.
- Bintrafusp alfa for patients with recurrent or metastatic olfactory neuroblastoma.Cancer immunology, immunotherapy : CII · 2026Trial
- Pan-cancer analysis and mechanistic insights of tuft cell-like tumors.Genes & diseases · 2026Review
- Sellar region neurocytomas exhibit a CIMP and neuroendocrine-like epigenetic signature distinct from other intra-axial neurocytomas.Acta neuropathologica · 2026Article
- Pathological Pathways of Olfactory Neuroblastoma: From Molecular Mechanisms to Targeted Therapy: A Narrative Review.Cancers · 2026Review
- A Multistep Immune-Competent Genetically Engineered Mouse Model Reveals Phenotypic Plasticity in Uveal Melanoma.Cancer research · 2026Article
- Single-Cell and Spatial Transcriptomics Reframe the Immunosuppressive Microenvironment of Neuroendocrine Neoplasms.Cancers · 2026Review
- Cancer Heterogeneity and Cancer Cell Plasticity: Molecular Mechanisms and Precision Therapy.MedComm · 2026Review
- Molecular Profiling of Olfactory Neuroblastoma Using the AACR Project GENIE Database.Journal of neurological surgery. Part B, Skull base · 2026Article
- Omics-based exploration of biomarkers and therapeutic targets in olfactory neuroblastoma.Discover oncology · 2026Review
- Olfactory Groove Schwannoma: a rare case report.Discover oncology · 2026Article
- DNA Virus Detection in Olfactory Neuroblastomas Using Targeted Enrichment NGS.Neuropathology : official journal of the Japanese Society of Neuropathology · 2026Article
- Diagnostic challenges in hepatic metastatic olfactory neuroblastoma: a case report and literature review.Discover oncology · 2026Article
- Small Cell Lung Cancer Classification: Unraveling Heterogeneity to Enable Personalized Treatments.Cancer research · 2026Review
- EZH2 Suppression Diversifies Prostate Cancer Lineage Variant Evolution and Lacks Efficacy in Inhibiting Disease Progression.Cancer research · 2026Article
- Investigation of Intercellular Trafficking of Global Glycosylphosphatidylinositol-Anchored Proteins Using Cell Metabolic Engineering and Transwell Coculture.Angewandte Chemie (International ed. in English) · 2026Article
- Tuft Cells in the Gut Limit Cognitive Disorders by Regulating Gut Homeostasis.Cellular and molecular gastroenterology and hepatology · 2026Article
- Systemic Therapy for High-Grade Olfactory Neuroblastoma: From Molecular Lineages to Targeted and Immune Strategies.Cancer management and research · 2026Review
- Understanding cancer as a systemic disease through comprehension of neural stemness as the core property of cancer cell and the basic rules it dictates.Frontiers in cell and developmental biology · 2026Review
- Advancing small cell lung cancer metastasis research: innovations in preclinical mouse models.Cancer metastasis reviews · 2025Review
- Article
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Authors and funding
12 authors.
John B FinlayDepartment of Head and Neck Surgery & Communication Sciences, Duke University, Durham 27710, NC, USA.
Abbie S IrelandDepartment of Pharmacology and Cancer Biology, Duke University, Durham 27710, NC, USA.
Sarah B HawgoodDepartment of Pharmacology and Cancer Biology, Duke University, Durham 27710, NC, USA.
Tony ReyesDepartment of Pharmacology and Cancer Biology, Duke University, Durham 27710, NC, USA; Department of Oncological Sciences, University of Utah, Salt Lake City 84112, UT, USA.
Tiffany KoDepartment of Head and Neck Surgery & Communication Sciences, Duke University, Durham 27710, NC, USA.
Rachelle R OlsenDepartment of Oncological Sciences, University of Utah, Salt Lake City 84112, UT, USA.
Ralph Abi HachemDepartment of Head and Neck Surgery & Communication Sciences, Duke University, Durham 27710, NC, USA.
David W JangDepartment of Head and Neck Surgery & Communication Sciences, Duke University, Durham 27710, NC, USA.
Diana BellDivision of Anatomic Pathology, City of Hope Comprehensive Cancer Center, Duarte 91010, CA, USA.
Joseph M ChanHuman Oncology and Pathogenesis Program, Memorial-Sloan Kettering Cancer Center, New York City 10065, NY, USA.
Bradley J GoldsteinDepartment of Head and Neck Surgery & Communication Sciences, Duke University, Durham 27710, NC, USA; Department of Neurobiology, Duke University, Durham 27710, NC, USA. Electronic address: bradley.goldstein@duke.edu.
Trudy G OliverDepartment of Pharmacology and Cancer Biology, Duke University, Durham 27710, NC, USA; Department of Oncological Sciences, University of Utah, Salt Lake City 84112, UT, USA. Electronic address: tgo@duke.edu.
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Michael Jason de la Cruz · 1985 to 2026
$347.4MWomen's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI Shannon Jones McCall · 1985 to 2026
$174.8MCoordinating center for the NCI small cell lung cancer research consortiumU24CA213274 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Lauren Averett Byers, JOHN D. MINNA · 2017 to 2026
$12.9MWashington University Paul Calabresi K12 Career Development Award for Clinical OncologyK12CA167540 · NCI · WASHINGTON UNIVERSITY · PI John F. Dipersio, Ramaswamy Govindan · 2012 to 2026
$11.7MCooperative Human Tissue Network Support through Duke's BioRepository & Precision Pathology CenterUM1CA239755 · NCI · DUKE UNIVERSITY · PI Shannon Jones McCall · 2019 to 2026
$5.4MGenomic and Functional Identification of Chemotherapy Resistance Mechanisms in Small Cell Lung CancerU01CA231844 · NCI · WASHINGTON UNIVERSITY · PI GOVINDAN, RAMASWAMY, GRIFFITH, OBI L. · 2018 to 2022
$3.1MTherapeutic potential for modulation of olfactory basal stem cellsR01DC016859 · NIDCD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GOLDSTEIN, BRADLEY J · 2018 to 2022
$2.2MUncovering Epigenetic and Transcriptional Drivers of Neuroendocrine Plasticity at Single-Cell Level in Patients with Small Cell Lung Cancer TransformationK08CA259161 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Joseph Minhow Chan · 2022 to 2026
$1.3MInvestigating and targeting metabolic vulnerabilities of MYC-driven small cell lung cancerF31CA275295 · NCI · DUKE UNIVERSITY · PI IRELAND, ABBIE SHAYE · 2022 to 2024
$143kLeveraging multi-omics to define the role of epigenetic regulation by PRC2 in EsthesioneuroblastomaF30DC021348 · NIDCD · DUKE UNIVERSITY · PI FINLAY, JOHN BARRATT · 2023 to 2024
$88kNCI NIH HHS F31 CA275295NCI NIH HHS K08 CA259161NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA014236NCI NIH HHS U01 CA231844NCI NIH HHS U24 CA213274NCI NIH HHS UM1 CA239755NIDCD NIH HHS F30 DC021348NIDCD NIH HHS R01 DC016859
Abstract
The olfactory epithelium undergoes neuronal regeneration from basal stem cells and is susceptible to olfactory neuroblastoma (ONB), a rare tumor of unclear origins. Employing alterations in Rb1/Trp53/Myc (RPM), we establish a genetically engineered mouse model of high-grade metastatic ONB exhibiting a NEUROD1
Indexed as
Cell LineageEsthesioneuroblastoma, OlfactoryLung NeoplasmsSmall Cell Lung CarcinomaAnimalsBasic Helix-Loop-Helix ProteinsDisease Models, AnimalHumansMiceNose NeoplasmsOlfactory MucosaTumor MicroenvironmentTumor Suppressor Protein p53ASCL1 protein, humanAscl1 protein, mouseBasic Helix-Loop-Helix ProteinsTumor Suppressor Protein p53ASCL1esthesioneuroblastomaNEUROD1neuroendocrineolfactory neuroblastomaplasticityPOU2F3RPMSCLCtuft
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.