Evidence map›Paper›PMID 38788523›Full record

ReviewCurrent opinion in chemical biology2024

Biosynthesis of isonitrile lipopeptides.

Kaimin Jia, Helen Sun, Yiyan Zhou, Wenjun Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in chemical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Copper-chelating natural products.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kaimin JiaDepartment of Chemical and Biomolecular Engineering, University of California Berkeley, Berkeley, CA 94720, United States; California Institute for Quantitative Biosciences, University of California Berkeley, Berkeley, CA 94720, United States.
Helen SunDepartment of Chemical and Biomolecular Engineering, University of California Berkeley, Berkeley, CA 94720, United States.
Yiyan ZhouDepartment of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, United States.
Wenjun ZhangDepartment of Chemical and Biomolecular Engineering, University of California Berkeley, Berkeley, CA 94720, United States; California Institute for Quantitative Biosciences, University of California Berkeley, Berkeley, CA 94720, United States. Electronic address: wjzhang@berkeley.edu.

Funding

Biosynthesis of unusual bio-orthogonal functionalities in natural productsR01GM136758 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ZHANG, WENJUN · 2020 to 2023
$1.5M
Biosynthesis of Unusual Bio-Orthogonal Functionalities in Natural ProductsR35GM153289 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Wenjun Zhang · 2024 to 2026
$1.1M
NIGMS NIH HHS R01 GM136758NIGMS NIH HHS R35 GM153289
6 · The paper itself

Abstract

Isonitrile lipopeptides discovered from Actinobacteria have attracted wide attention due to their fascinating biosynthetic pathways and relevance to the virulence of many human pathogens including Mycobacterium tuberculosis. Specifically, the identification of the new class of isonitrile-forming enzymes that belong to non-heme iron (II) and α-ketoglutarate dependent dioxygenases has intrigued several research groups to investigate their catalytic mechanism. Here we summarize the recent studies on the biosynthesis of isonitrile lipopeptides from Streptomyces and Mycobacterium. The latest research on the core and tailoring enzymes involved in the pathway as well as the isonitrile metabolic enzymes are discussed in this review.

Indexed as

LipopeptidesNitrilesBiosynthetic PathwaysHumansMycobacteriumStreptomycesLipopeptidesNitrilesBiosynthesisDioxygenaseIsonitrile lipopeptideMetal transportMycobacteriumNonribosomal peptide synthetase

Identifiers

PMID38788523
PMCPMC11323250

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.