Evidence map›Paper›PMID 38787930›Full record

ArticleStroke2024

Comparing Outcomes of Thrombectomy Versus Intravenous Thrombolysis Based on Middle Cerebral Artery M2 Occlusion Features.

Huan Zhou, Wansi Zhong, Tingxia Zhang, Chenghua Xu, Genlong Zhong, Guomin Xie, Bing Zhang, Hongfang Chen, En Wang, Dongjuan Xu and 5 more

Registry-linked trialAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04487340 (Computer-based Online Database of Acute Stroke Patients for Stroke Management Quality Evaluation), which is not on this map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04487340 recruitingnot on this map

Computer-based Online Database of Acute Stroke Patients for Stroke Management Quality Evaluation

Typeobservational_patient_registrySponsorSecond Affiliated Hospital, Zhejiang University, School of MedicineRan2016 to 2028Enrolled200,000ConditionsStroke, AcuteArmsEducation
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Efficacy and Safety of Intravenous Thrombolytics in Ischemic Stroke Beyond the 4.5-Hour Time Window: A Systematic Review and Meta-Analysis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Pooled it
  3. Trial
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Huan Zhou *Department of Neurology, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China (H.Z., W.Z., T.Z., J.Y., M.L., S.Y.).
Wansi Zhong *Department of Neurology, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China (H.Z., W.Z., T.Z., J.Y., M.L., S.Y.).
Tingxia ZhangDepartment of Neurology, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China (H.Z., W.Z., T.Z., J.Y., M.L., S.Y.).
Chenghua XuDepartment of Neurology, Taizhou First People's Hospital, China (C.X.).
Genlong ZhongDepartment of Neurology, The Sixth Affiliated Hospital of Wenzhou Medical University, The People's Hospital of Lishui, China (G.Z.).ORCID 0000-0002-2147-258X
Guomin XieDepartment of Neurology, Ningbo Medical Center Li Huili Hospital, China (G.X.).ORCID 0009-0001-5065-1448
Bing ZhangDepartment of Neurology, Huzhou Central Hospital, China (B.Z.).
Hongfang ChenDepartment of Neurology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, China (H.C.).
En WangDepartment of Neurology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, China (E.W.).
Dongjuan XuDepartment of Neurology, Dongyang Affiliated Hospital of Wenzhou Medical University, China (D.X.).
Chaochan ChengDepartment of Neurology, The First People's Hospital of Yongkang, China (C.C.).
Jiansheng YangDepartment of Neurology, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China (H.Z., W.Z., T.Z., J.Y., M.L., S.Y.).
Min LouDepartment of Neurology, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China (H.Z., W.Z., T.Z., J.Y., M.L., S.Y.).ORCID 0000-0002-6627-064X
Shenqiang YanDepartment of Neurology, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China (H.Z., W.Z., T.Z., J.Y., M.L., S.Y.).ORCID 0000-0001-6425-0672
CASE-II Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCurrent evidence provides limited support for the superiority of endovascular thrombectomy (EVT) in patients with M2 segment middle cerebral artery occlusion. We aim to investigate whether imaging features of M2 segment occlusion impact the effectiveness of EVT.

methodsWe conducted a retrospective cohort study from January 2017 to January 2022, drawing data from the CASE II registry (Computer-Based Online Database of Acute Stroke Patients for Stroke Management Quality Evaluation), which specifically documented patients with acute ischemic stroke presenting with M2 segment occlusion undergoing reperfusion therapy. Patients were stratified into the intravenous thrombolysis (IVT) group (IVT alone) and EVT group (IVT plus EVT or EVT alone). The primary outcome was a modified Rankin Scale score 0 to 2 at 90 days. Secondary outcomes included additional thresholds and distribution of modified Rankin Scale scores, 24-hour recanalization, early neurological deterioration, and relevant complications during hospitalization. Safety outcomes encompassed intracranial hemorrhagic events at 24 hours and mortality at 90 days. Binary logistic regression analyses with propensity score matching were used. Subgroup analyses were performed based on the anatomic site of occlusion, including right versus left, proximal versus distal, dominant/co-dominant versus nondominant, single versus double/triple branch(es), and anterior versus central/posterior branch.

resultsAmong 734 patients (43.3% were females; median age, 73 years) with M2 segment occlusion, 342 (46.6%) were in the EVT group. Propensity score matching analysis revealed no statistical difference in the primary outcome (odds ratio, 0.860 [95% CI, 0.611-1.209];

conclusionsOur study showed similar efficiency of EVT versus IVT alone in acute M2 segment middle cerebral artery occlusion. This suggested that only specific patient subpopulations might have a potentially higher benefit of EVT over IVT alone. REGISTRATION: URL: https://clinicaltrials.gov; Unique identifier: NCT04487340.

Indexed as

Infarction, Middle Cerebral ArteryThrombectomyThrombolytic TherapyAgedAged, 80 and overEndovascular ProceduresFemaleHumansIschemic StrokeMaleMiddle AgedRegistriesRetrospective StudiesTreatment Outcomecerebrovascular occlusionischemic strokeoutcome assessmentthrombectomythrombolytic therapy

Identifiers

PMID38787930
PMCPMC11122739

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.