Evidence map›Paper›PMID 38787877›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Unplugging lateral fenestrations of NALCN reveals a hidden drug binding site within the pore region.

Katharina Schott, Samuel George Usher, Oscar Serra, Vincenzo Carnevale, Stephan Alexander Pless, Han Chow Chua

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Katharina SchottDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen 2100, Denmark.ORCID 0000-0002-9872-2372
Samuel George UsherDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen 2100, Denmark.
Oscar SerraDepartment of Biology, Temple University, Philadelphia, PA 19122.
Vincenzo CarnevaleDepartment of Biology, Temple University, Philadelphia, PA 19122.ORCID 0000-0002-1918-8280
Stephan Alexander PlessDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen 2100, Denmark.ORCID 0000-0001-6654-114X
Han Chow ChuaDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen 2100, Denmark.ORCID 0000-0003-4477-174X

Funding

Regulation of the Intestinal Ca2+ Channels TRPV6R01GM093290 · NIGMS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI CARNEVALE, VINCENZO, ROHACS, TIBOR · 2011 to 2025
$4.9M
Carlsbergfondet (Carlsberg Foundation) CF16-0504Danmarks Frie Forskningsfond (DFF) 7025-00097ADanmarks Frie Forskningsfond (DFF) 9124-00002BDOD | USA | AFC | CCDC | DEVCOM Army Research Laboratory (DEVCOM ARL) W911NF-16-2-0189HHS | NIH | National Institute of General Medical Sciences (NIGMS) R01GM093290Lundbeck Foundation (Lundbeckfonden) R252-2017-1671Lundbeck Foundation (Lundbeckfonden) R383-2022-165National Science Foundation (NSF) 1625061NIGMS NIH HHS R01 GM093290
6 · The paper itself

Abstract

The sodium (Na

Indexed as

PhenytoinAnimalsBinding SitesBoron CompoundsHEK293 CellsHumansIon ChannelsMembrane ProteinsNerve Tissue Proteins2-aminoethoxydiphenyl borateBoron CompoundsIon ChannelsMembrane ProteinsNALCN protein, humanNerve Tissue ProteinsPhenytoinion channelslateral fenestrationsNALCNvoltage-gated calcium channelsvoltage-gated sodium channels

Identifiers

PMID38787877
PMCPMC11145269

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.