Evidence map›Paper›PMID 38787839›Full record

Trial reportPloS one2024

Diaphragm thickness and mobility elicited by two different modalities of inspiratory muscle loading in heart failure participants: A randomized crossover study.

Tatiana Zacarias Rondinel, Lilian Bocchi, Gerson Cipriano Júnior, Gaspar Rogério da Silva Chiappa, Gabriela de Sousa Martins, Sérgio Ricardo Menezes Mateus, Lawrence Patrick Cahalin, Graziella França Bernardelli Cipriano

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07688863 (Effects of Inspiratory Muscle Training on Maximal Inspiratory Pressure, Cardiopulmonary Capacity, and Quality of Life in Patients With Heart Failure), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07688863 naenrolling by invitationnot on this mapstarted 2026, after this paper: background citation

Effects of Inspiratory Muscle Training on Maximal Inspiratory Pressure, Cardiopulmonary Capacity, and Quality of Life in Patients With Heart Failure

TypeinterventionalSponsorUniversidad Nacional Andres BelloRan2026 to 2027Enrolled60ConditionsHeart Failure, Heart Failure and Reduced Ejection Fraction, Heart Failure and Mildly Reduced Ejection Fraction, Muscle WeaknessArmsMechanical Pressure-Threshold IMT Device, PowerBreathe KH2 Electronic IMT Device, Sub-therapeutic Mechanical IMT Device (Sham)
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tatiana Zacarias RondinelScience and Technology in Health Program, University of Brasília, Brasília, Distrito Federal, Brazil.ORCID 0000-0002-1332-2880
Lilian BocchiPhysical Therapy Department, Science of Rehabilitation Program, University of Brasília, Brasília, Distrito Federal, Brazil.
Gerson Cipriano JúniorPhysical Therapy Department, Science of Rehabilitation Program, University of Brasília, Brasília, Distrito Federal, Brazil.
Gaspar Rogério da Silva ChiappaCentro Universitário de Anápolis, Anápolis, Goiás, Brazil.
Gabriela de Sousa MartinsPhysical Therapy Department, Science of Rehabilitation Program, University of Brasília, Brasília, Distrito Federal, Brazil.
Sérgio Ricardo Menezes MateusPhysical Therapy Department, University of Brasília, Brasília, Distrito Federal, Brazil.ORCID 0000-0002-0160-8267
Lawrence Patrick CahalinDepartment of Physical Therapy, Leonard M. Miller School of Medicine, University of Miami, Coral Gables, Florida, United States of America.
Graziella França Bernardelli CiprianoPhysical Therapy Department, Science of Rehabilitation Program, University of Brasília, Brasília, Distrito Federal, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo analyze diaphragmatic thickness, at end-inspiration and end-expiration, diaphragmatic thickening index and mobility via US under two different modalities of inspiratory muscle loading, in two different modalities of inspiratory muscle loading and different load intensities at full-vital capacity maneuvers and the relationship between diaphragmatic thickness with pulmonary function tests in participants with HF.

methodsThis randomized crossover trial, enrolled with 17 HF subjects, evaluated diaphragm thickness (Tdi, mm), fractional thickness (TFdi, %), and mobility (mm) US during low and high intensities (30% and 60% of maximal inspiratory pressure-MIP) with two modalities of inspiratory muscle loading mechanical threshold loading (MTL) and tapered flow-resistive loading (TFRL).

resultsBoth MTL and TFRL produced a increase in Tdi, but only with high intensity loading compared to baseline-2.21 (0.26) vs. 2.68 (0.33) and 2.73 (0.44) mm; p = .01. TFdi was greater than baseline under all conditions, except during low intensity of TFRL. Diaphragm mobility was greater than baseline under all conditions, and high intensity of TFRL elicited greater mobility compared to all other conditions. Additionally, baseline Tdi was moderately correlated with pulmonary function tests.

conclusionsMTL and TFRL modalities elicit similar increases in diaphragm thickness at loads, but only during high intensity loading it was greater than baseline. Diaphragm mobility was significantly greater than baseline under both loads and devices, and at high intensity compared to low intensity, although TFRL produced greater mobility compared to modalities of inspiratory muscle loading. There is an association between diaphragm thickness and pulmonary function tests.

Indexed as

Cross-Over StudiesDiaphragmHeart FailureInhalationAgedFemaleHumansMaleMiddle AgedRespiratory Function TestsRespiratory Muscles

Identifiers

PMID38787839
PMCPMC11125520

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.