Evidence map›Paper›PMID 38787793›Full record

ArticleJournal of medicinal chemistry2024

Structure-Based Design of a Potent and Selective YTHDC1 Ligand.

František Zálešák, Francesco Nai, Marcin Herok, Elena Bochenkova, Rajiv K Bedi, Yaozong Li, Francesco Errani, Amedeo Caflisch

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. NNature reviews. Cancer · 2026
    Review
  6. Article
  7. Review
  8. Article
  9. RNA modification systems as therapeutic targets.Nature reviews. Drug discovery · 2026
    Review
  10. mActa pharmaceutica Sinica. B · 2025
    Review
  11. Article
  12. The mMolecular biomedicine · 2025
    Review
  13. Article
  14. The physics-AI dialogue in drug design.RSC medicinal chemistry · 2025
    Review
  15. Review
  16. Effects of mFrontiers in aging neuroscience · 2025
    Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

František ZálešákDepartment of Biochemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
Francesco NaiDepartment of Biochemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.ORCID 0000-0002-4258-3174
Marcin HerokDepartment of Biochemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
Elena BochenkovaDepartment of Biochemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
Rajiv K BediDepartment of Biochemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.ORCID 0000-0002-8193-9006
Yaozong LiDepartment of Biochemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.ORCID 0000-0002-5796-2644
Francesco ErraniDepartment of Biochemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.ORCID 0009-0004-4658-9022
Amedeo CaflischDepartment of Biochemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.ORCID 0000-0002-2317-6792

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

N

Indexed as

Drug DesignAntineoplastic AgentsCell Line, TumorCell ProliferationCrystallography, X-RayHeterocyclic Compounds, 2-RingHumansLigandsModels, MolecularNerve Tissue ProteinsRNA Splicing FactorsStructure-Activity RelationshipAntineoplastic AgentsHeterocyclic Compounds, 2-RingLigandsNerve Tissue ProteinsRNA Splicing FactorsYTHDC1 protein, human

Identifiers

PMID38787793
PMCPMC11181329

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.