Evidence map›Paper›PMID 38787758›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Heterogeneous blood-brain barrier dysfunction in cerebral small vessel diseases.

Yunqing Ying, Yingying Li, Tingyan Yao, Xingfeng Shao, Weijun Tang, Axel Montagne, Hugues Chabriat, Danny J J Wang, Chaodong Wang, Qi Yang and 1 more

Abstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Simultaneous measurement of water transport across the blood-brain and blood-CSF barrier in the human brain with arterial spin labeling MRI.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
  7. Review
  8. Article
  9. Observational
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. MAPK signaling and angiopoietin-2 contribute to endothelial permeability in capillary malformations.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yunqing YingDepartment of Neurology, National Center for Neurological Disorders, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Yingying LiDepartment of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Tingyan YaoDepartment of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing, China.
Xingfeng ShaoLaboratory of FMRI Technology (LOFT), USC Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Weijun TangDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
Axel MontagneCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Hugues ChabriatCentre Neurovasculaire Translationnel, CERVCO, INSERM U1141, FHU NeuroVasc, Université Paris Cité, Paris, France.
Danny J J WangLaboratory of FMRI Technology (LOFT), USC Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Chaodong WangDepartment of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing, China.
Qi YangDepartment of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Xin ChengDepartment of Neurology, National Center for Neurological Disorders, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.

Funding

BBB Permeability Imaging in CADASILR01NS114382 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI WANG, DANNY JJ · 2020 to 2024
$1.2M
National Natural Science Foundation of China 81961128030National Natural Science Foundation of China 81971123National Natural Science Foundation of China 82025018National Natural Science Foundation of China 82271352National Natural Science Foundation of China 92249301NINDS NIH HHS R01 NS114382Science and Technology Commission of Shanghai Municipality 20Z11900802Shanghai Municipal Health Commission 2022XD022US National Institutes of Health R01NS114382
6 · The paper itself

Abstract

introductionWe explored how blood-brain barrier (BBB) leakage rate of gadolinium chelates (K

methodsThirty sporadic cSVD, 40 cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), and 13 high-temperature requirement factor A serine peptidase 1 (HTRA) -related cSVD subjects were investigated parallel to 40 healthy individuals. Subjects underwent clinical, cognitive, and MRI assessment.

resultsIn CADASIL, no difference in K DISCUSSION: In cSVD subtypes, distinct alterations of k HIGHLIGHTS: We measured BBB leakage to gadolinium-based contrast agent (K

Indexed as

Blood-Brain BarrierCerebral Small Vessel DiseasesMagnetic Resonance ImagingAdultAgedBrainCADASILContrast MediaFemaleGadoliniumHigh-Temperature Requirement A Serine Peptidase 1HumansMaleMiddle AgedContrast MediaGadoliniumHigh-Temperature Requirement A Serine Peptidase 1HTRA1 protein, humanBlood‐brain barrierCADASILcerebral small vessel diseaseHTRA1‐related cSVDmagnetic resonance imaging

Identifiers

PMID38787758
PMCPMC11247670

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.