Evidence map›Paper›PMID 38787492›Full record

ArticleMolecular neurobiology2024

Isavuconazole Induces Neurodevelopment Defects and Motor Behaviour Impairment in Zebrafish Larvae.

Li Zhang, Xue Li, Qiang Yuan, Sujie Sun, Fasheng Liu, Xinjun Liao, Huiqiang Lu, Jianjun Chen, Zigang Cao

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Li ZhangJiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Jiangxi Key Laboratory of Developmental Biology of Organs and Epigenetics, College of Life Sciences, Affiliated Hospital of Jinggangshan University, Clinical Research Center of Affiliated Hospital of Jinggangshan University, Jinggangshan University, Ji'an, 343009, China.
Xue LiJiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Jiangxi Key Laboratory of Developmental Biology of Organs and Epigenetics, College of Life Sciences, Affiliated Hospital of Jinggangshan University, Clinical Research Center of Affiliated Hospital of Jinggangshan University, Jinggangshan University, Ji'an, 343009, China.
Qiang YuanJiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Jiangxi Key Laboratory of Developmental Biology of Organs and Epigenetics, College of Life Sciences, Affiliated Hospital of Jinggangshan University, Clinical Research Center of Affiliated Hospital of Jinggangshan University, Jinggangshan University, Ji'an, 343009, China.
Sujie SunTranslational Research Institute of Brain and Brain-Like Intelligence, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Department of Pediatrics, School of Medicine, Shanghai Fourth People's Hospital, Tongji University, Shanghai, 200434, China.
Fasheng LiuJiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Jiangxi Key Laboratory of Developmental Biology of Organs and Epigenetics, College of Life Sciences, Affiliated Hospital of Jinggangshan University, Clinical Research Center of Affiliated Hospital of Jinggangshan University, Jinggangshan University, Ji'an, 343009, China.
Xinjun LiaoJiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Jiangxi Key Laboratory of Developmental Biology of Organs and Epigenetics, College of Life Sciences, Affiliated Hospital of Jinggangshan University, Clinical Research Center of Affiliated Hospital of Jinggangshan University, Jinggangshan University, Ji'an, 343009, China.
Huiqiang LuJiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Jiangxi Key Laboratory of Developmental Biology of Organs and Epigenetics, College of Life Sciences, Affiliated Hospital of Jinggangshan University, Clinical Research Center of Affiliated Hospital of Jinggangshan University, Jinggangshan University, Ji'an, 343009, China.
Jianjun ChenTranslational Research Institute of Brain and Brain-Like Intelligence, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Department of Pediatrics, School of Medicine, Shanghai Fourth People's Hospital, Tongji University, Shanghai, 200434, China. chenjianjun@tongji.edu.cn.
Zigang CaoJiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Jiangxi Key Laboratory of Developmental Biology of Organs and Epigenetics, College of Life Sciences, Affiliated Hospital of Jinggangshan University, Clinical Research Center of Affiliated Hospital of Jinggangshan University, Jinggangshan University, Ji'an, 343009, China. zigangcao@126.com.ORCID http://orcid.org/0000-0002-8463-4996

Funding

20204BCJL23043 Jiangxi Province's major academic20204BCJL23043 technical leaders training plan for young talents2020YFA0112500 Technology of China2020YFA0112500 The Ministry of Science2021YFA1101300 Technology of China2021YFA1101300 The Ministry of Science20224ACB215001 Natural Science Foundation Project of Jiangxi Province for Distinguished Young Scholars32370896 the National Natural Science FoundationGJJ211004 Jiangxi Provincial Department of Education ScienceGJJ211004 Technology Program Projectjxsq2023201122 Jiangxi Province's "Double Thousand Plan" Technology High end Innovative Talents
6 · The paper itself

Abstract

Isavuconazole is a broad-spectrum antifungal drug used for the treatment of serious infections caused by invasive aspergillosis and mucormycosis in adults. With the continuous use of this drug, its safety and environmental impact have received increasing attention. However, information on the adverse effects of the drug is very limited. Fish is a particularly important model for assessing environmental risks. In this study, the aquatic vertebrate zebrafish was used as a model to study the toxic effects and mechanisms of isavuconazole. We exposed zebrafish embryos to 0.25, 0.5, and 1 mg/L of isavuconazole 6 h after fertilization. The results showed that at 72 hpf, isavuconazole exposure reduced heart rate, body length, and survival of zebrafish embryos compared to controls. Secondly, when isavuconazole reached a certain dose level (0.25 mg/L), it caused morphological changes in the Tg(elavl3:eGFP) transgenic fish line, with the head shrunk, the body bent, the fluorescence intensity becoming weaker, the abnormal motor behaviour, etc. At the same time, exposure of zebrafish embryos to isavuconazole downregulated acetylcholinesterase (AchE) and adenosine triphosphate (ATPase) activities but upregulated oxidative stress, thereby disrupting neural development and gene expression of neurotransmitter pathways. In addition, astaxanthin partially rescued the neurodevelopmental defects of zebrafish embryos by downregulating oxidative stress. Thus, our study suggests that isavuconazole exposure may induce neurodevelopment defects and behavioural disturbances in larval zebrafish.

Indexed as

LarvaMotor ActivityNitrilesPyridinesTriazolesZebrafishAcetylcholinesteraseAnimalsAnimals, Genetically ModifiedBehavior, AnimalEmbryo, NonmammalianOxidative StressAcetylcholinesteraseisavuconazoleNitrilesPyridinesTriazolesBehavioural disturbanceIsavuconazoleNeurotoxicityZebrafish embryo

Identifiers

PMID38787492

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.