Evidence map›Paper›PMID 38787477›Full record

ArticleClinical rheumatology2024

Interactions of cumulative load with biomarkers of cartilage turnover predict knee cartilage change over 2 years: data from the osteoarthritis initiative.

Natasha K Ivanochko, Anthony A Gatti, Paul W Stratford, Monica R Maly

Abstract read
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In one paragraph

Article in Clinical rheumatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Relationships Between the Infrapatellar Fat Pad and Patellofemoral Joint Osteoarthritis Differ With Body Mass Index and Sex.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Natasha K IvanochkoDepartment of Kinesiology and Health Sciences, University of Waterloo, Room 1036 Burt Matthews Hall, 200 University Avenue, Waterloo, ON, N2L 3G1, Canada.
Anthony A GattiDepartment of Radiology, Stanford University, Stanford, USA.
Paul W StratfordSchool of Rehabilitation Science, McMaster University, Hamilton, Canada.
Monica R MalyDepartment of Kinesiology and Health Sciences, University of Waterloo, Room 1036 Burt Matthews Hall, 200 University Avenue, Waterloo, ON, N2L 3G1, Canada. mrmaly@uwaterloo.ca.ORCID http://orcid.org/0000-0001-5414-3777

Funding

Natural Sciences and Engineering Research Council of Canada 353715The Arthritis Society & CIHR Institute of Musculoskeletal Health and Arthritis STAR 2019
6 · The paper itself

Abstract

The purpose was to investigate relationships of cumulative load and cartilage turnover biomarkers with 2-year changes in cartilage in knee osteoarthritis. From participants with Kellgren-Lawrence (KL) grades of 1 to 3, cartilage thickness and transverse relaxation time (T2) were computed from 24-month (baseline) and 48-month magnetic resonance images. Cumulative load was the interaction term of the Physical Activity Scale for the Elderly (PASE) and body mass index (BMI). Serum cartilage oligomeric matrix protein (COMP) and the nitrated form of type II collagen (Coll2-1 NO2) were collected at baseline. Multiple regressions (adjusted for baseline age, KL grade, cartilage measures, pain, comorbidity) evaluated the relationships of cumulative load and biomarkers with 2-year changes. In 406 participants (63.7 (8.7) years), interactions of biomarkers with cumulative load weakly predicted 2-year cartilage changes: (i) COMP × cumulative load explained medial tibia thickness change (R

Indexed as

BiomarkersCartilage, ArticularCartilage Oligomeric Matrix ProteinCollagen Type IIKnee JointMagnetic Resonance ImagingOsteoarthritis, KneeAgedBody Mass IndexDisease ProgressionFemaleHumansMaleMiddle AgedWeight-BearingBiomarkersCartilage Oligomeric Matrix ProteinCollagen Type IITSP5 protein, humanBiomechanical phenomenaComputerExerciseMagnetic resonance imagingNeural networksObesity

Identifiers

PMID38787477

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.