Evidence map›Paper›PMID 38787459›Full record

ArticleJournal of natural medicines2024

Scutellaria Root extract-induced hepatocytotoxicity can be controlled by regulating its baicalin content.

Naohiro Oshima, Kosuke Kusamori, Ryo Takasaki, Moe Takeda, Yuri Katsurada, Takumi Nose, Kazuki Okoshi, Makiya Nishikawa, Noriyasu Hada

Abstract read
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In one paragraph

Article in Journal of natural medicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Naohiro Oshima *Laboratory of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda City, Chiba, 278-8510, Japan. n-oshima@nihs.go.jp.
Kosuke Kusamori *Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda City, Chiba, 278-8510, Japan.
Ryo TakasakiLaboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda City, Chiba, 278-8510, Japan.
Moe TakedaLaboratory of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda City, Chiba, 278-8510, Japan.
Yuri KatsuradaLaboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda City, Chiba, 278-8510, Japan.
Takumi NoseLaboratory of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda City, Chiba, 278-8510, Japan.
Kazuki OkoshiLaboratory of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda City, Chiba, 278-8510, Japan.
Makiya NishikawaLaboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda City, Chiba, 278-8510, Japan. makiya@rs.tus.ac.jp.
Noriyasu HadaLaboratory of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda City, Chiba, 278-8510, Japan. hada@rs.tus.ac.jp.

Funding

Japan Society for the Promotion of Science 22K06676
6 · The paper itself

Abstract

Scuellaria Root (SR, root of Scutellaria baicalensis), which has potent anti-inflammatory effects, is a component of useful Kampo formulae. Albeit a low frequency, SR induces serious interstitial pneumonia and liver dysfunction. In this study, to control the adverse effects of SR, we investigated the causal constituent responsible for its hepatocytotoxicity and aimed to develop a method to control it. As a result, we revealed that the hepatocytotoxicity of SR was correlated with its baicalin content, a major constituent in SR. It was confirmed by preparing a baicalin-free SR extract, which exhibited reduced hepatocytotoxicity. The addition of baicalin to the baicalin-free SR extract restored the hepatocytotoxicity, indicating that the hepatocytotoxicity of SR is dependent on its baicalin content. Thus, SR extract-induced hepatocytotoxicity can be controlled by regulating its baicalin content.

Indexed as

FlavonoidsPlant ExtractsPlant RootsScutellaria baicalensisAnimalsChemical and Drug Induced Liver InjuryHumansLiverMicebaicalinFlavonoidsPlant ExtractsScutellaria baicalensis extractBaicalinHepatocytotoxicityScutellaria baicalensisScutellaria Root

Identifiers

PMID38787459

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.