Evidence map›Paper›PMID 38787452›Full record

ArticleActa neurochirurgica2024

Intra-operative extracorporeal irradiation of tumour-invaded craniotomy bone flap in meningioma: a case series.

William H Cook, Katherine Burton, Sarah J Jefferies, Simon L Duke, Rajesh Jena, Neil G Burnet, Ramez W Kirollos, Adel E Helmy, Thomas Santarius

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Article in Acta neurochirurgica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

William H CookDivision of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. whc35@cam.ac.uk.ORCID 0000-0001-7699-3342
Katherine BurtonDepartment of Radiation Oncology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Sarah J JefferiesDepartment of Oncology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Simon L DukeDepartment of Oncology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Rajesh JenaDepartment of Radiation Oncology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Neil G BurnetDepartment of Oncology, University of Cambridge, Cambridge, UK.
Ramez W KirollosDivision of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Adel E HelmyDivision of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Thomas SantariusDivision of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExtracorporeal irradiation of tumorous calvaria (EITC) can be performed to restore function and form of the skull after resection of bone-invasive meningioma. We sought to examine the rate of tumour recurrence and other selected outcomes in patients undergoing meningioma resection and EITC.

methodsRetrospective single-centre study of adult patients undergoing meningioma resection and EITC between January 2015 and November 2022 at a tertiary neurosurgical centre. Patient demographics, surgery data, tumour data, use of adjuvant therapy, surgical complications, and tumour recurrences were collected.

resultsEighteen patients with 11 (61%) CNS WHO grade 1, 6 (33%) grade 2, and 1 (6%) grade 3 meningiomas were included. Median follow-up was 42 months (range 3-88). Five (28%) patients had a recurrence, but none were associated with the bone flap. Two (11%) wound infections requiring explant surgery occurred. Six (33%) patients required a further operation. Two operations were for recurrences, one was for infection, one was a washout and wound exploration but no evidence of infection was found, one patient requested the removal of a small titanium implant, and one patient required a ventriculoperitoneal shunt for a persistent CSF collection. There were no cases of bone flap resorption and cosmetic outcome was not routinely recorded.

conclusionEITC is feasible and fast to perform with good outcomes and cost-effectiveness compared to other reconstructive methods. We observed similar recurrence rates and lower infection rates requiring explant compared to the largest series of cranioplasty in meningioma. Cosmetic outcome is universally under-reported and should be reported in future studies.

Indexed as

CraniotomyMeningeal NeoplasmsMeningiomaSurgical FlapsAdultAgedFemaleHumansMaleMiddle AgedNeoplasm Recurrence, LocalRetrospective StudiesTreatment OutcomeCase seriesMeningiomaRadiation oncologySkull neoplasms

Identifiers

PMID38787452
PMCPMC11126431

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