Evidence map›Paper›PMID 38787431›Full record

ArticleArchives of dermatological research2024

Neuroticism and inflammatory skin diseases: a bidirectional Mendelian randomization study.

Charalabos Antonatos, Alexandros Pontikas, Adam Akritidis, Sophia Georgiou, Alexander J Stratigos, Ileana Afroditi Kleidona, Stamatis Gregoriou, Katerina Grafanaki, Yiannis Vasilopoulos

Abstract read
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In one paragraph

Article in Archives of dermatological research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Molecular Link Between Psoriasis and Depression-Update on Pathophysiology.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Charalabos AntonatosLaboratory of Genetics, Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, 26504, Patras, Greece.
Alexandros PontikasLaboratory of Genetics, Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, 26504, Patras, Greece.
Adam AkritidisLaboratory of Genetics, Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, 26504, Patras, Greece.
Sophia GeorgiouDepartment of Dermatology-Venereology, School of Medicine, University of Patras, 26504, Patras, Greece.
Alexander J StratigosDepartment of Dermatology-Venereology, Faculty of Medicine, Andreas Sygros Hospital, National and Kapodistrian University of Athens, 16121, Athens, Greece.
Ileana Afroditi KleidonaDepartment of Dermatology-Venereology, Faculty of Medicine, Andreas Sygros Hospital, National and Kapodistrian University of Athens, 16121, Athens, Greece.
Stamatis GregoriouDepartment of Dermatology-Venereology, Faculty of Medicine, Andreas Sygros Hospital, National and Kapodistrian University of Athens, 16121, Athens, Greece.
Katerina GrafanakiDepartment of Dermatology-Venereology, School of Medicine, University of Patras, 26504, Patras, Greece. grafanaki@upatras.gr.
Yiannis VasilopoulosLaboratory of Genetics, Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, 26504, Patras, Greece. grafanaki@upatras.gr.

Funding

National Eczema Association NEA23-CRG186
6 · The paper itself

Abstract

Previous observational studies have linked inflammatory skin diseases with mental health issues and neuroticism. However, the specific impact of neuroticism and its subclusters (i.e. worry, depressed affect, and sensitivity to environmental stress and adversity) on these conditions remains underexplored. In this work, we explored causal associations between common inflammatory skin diseases and neuroticism. We conducted a two-sample, bidirectional Mendelian randomization (MR) analysis using data from genome-wide association studies in psoriasis, atopic dermatitis, neuroticism and relevant genetic subclusters conducted on participants of European ancestry. Corrections for sample overlap were applied where necessary. We found that psoriasis was causally associated with increased levels of worry (odds ratio, 95% confidence intervals: 1.011, 1.006-1.016, P = 3.84 × 10

Indexed as

Dermatitis, AtopicGenetic Predisposition to DiseaseGenome-Wide Association StudyMendelian Randomization AnalysisNeuroticismPsoriasisHumansPolymorphism, Single NucleotideAtopic dermatitisDepressive symptomsEnvironmental stressNeuroticismPsoriasisWorry

Identifiers

PMID38787431

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.