Evidence map›Paper›PMID 38787395›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2024

Development and evaluation of albumin binder-conjugated heterodimeric radiopharmaceuticals targeting integrin α

Biao Yang, Changyu Shan, Xiangming Song, Xiaoying Lv, Yu Long, Dexing Zeng, Rui An, Xiaoli Lan, Yongkang Gai

Abstract read
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Dual-Target Nectin-4/FAP Heterobivalent ProbeAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Phase I study of [European journal of nuclear medicine and molecular imaging · 2025
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Biao Yang *Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Changyu Shan *Hexin (Suzhou) Pharmaceutical Technology Co., Ltd, Taicang City, 215421, China.
Xiangming SongDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Xiaoying LvDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Yu LongDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Dexing ZengHexin (Suzhou) Pharmaceutical Technology Co., Ltd, Taicang City, 215421, China.
Rui AnDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. anruiwh@163.com.
Xiaoli LanDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. LXL730724@hotmail.com.
Yongkang GaiDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. gykmail@hust.edu.cn.ORCID 0000-0001-6766-5240

Funding

Hubei Provincial Key Laboratory of Molecular Imaging Open Fund 2021fzyx023Hubei Provincial Key Laboratory of Molecular Imaging Open Fund 2022fzyx008National Natural Science Foundation of China 81801738National Natural Science Foundation of China 82030052Natural Science Foundation of Hubei Province 2022CFB063
6 · The paper itself

Abstract

purposeThe advancement of heterodimeric tracers, renowned for their high sensitivity, marks a significant trend in the development of radiotracers for cancer diagnosis. Our prior work on [

methodsNew albumin binder-conjugated compounds were synthesized based on the structure of HX01. In vitro and in vivo evaluation of these new compounds were performed after labelling with

resultsWe have synthesized novel albumin binder-conjugated compounds, building upon the structure of HX01. When radiolabeled with

conclusionA new integrin α

Indexed as

Integrin alphaVbeta3RadiopharmaceuticalsAlbuminsAnimalsCell Line, TumorFemaleHumansMiceNeoplasmsPositron Emission Tomography Computed TomographyTissue DistributionAlbuminsIntegrin alphaVbeta3RadiopharmaceuticalsAlbumin binderCD13HeterodimericIntegrin αvβ3Radiopharmaceuticals

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.