Evidence map›Paper›PMID 38787114›Full record

ArticleToxics2024

Tert-Butylhydroquinone Mitigates T-2-Toxin-Induced Testicular Dysfunction by Targeting Oxidative Stress, Inflammation, and Apoptosis in Rats.

Yun Chen, Xinke Zhang, Shanshan Lan, Shuping Liang, Manyu Zhang, Shuang Zhang, Yijian Liu, Li Li, Hengxi Wei, Shouquan Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yun ChenGuangdong Provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region, College of Biology and Agriculture, Shaoguan University, Shaoguan 512005, China.
Xinke ZhangGuangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.ORCID 0009-0008-9564-9369
Shanshan LanGuangdong Provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region, College of Biology and Agriculture, Shaoguan University, Shaoguan 512005, China.
Shuping LiangGuangdong Provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region, College of Biology and Agriculture, Shaoguan University, Shaoguan 512005, China.
Manyu ZhangGuangdong Provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region, College of Biology and Agriculture, Shaoguan University, Shaoguan 512005, China.
Shuang ZhangGuangdong Provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region, College of Biology and Agriculture, Shaoguan University, Shaoguan 512005, China.
Yijian LiuGuangdong Provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region, College of Biology and Agriculture, Shaoguan University, Shaoguan 512005, China.
Li LiGuangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Hengxi WeiGuangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Shouquan ZhangGuangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.

Funding

Guangdong Basic and Applied Basic Research Foundation 2023A1515010232National Natural Science Foundation of China 32272873Project of Swine Innovation Team in Guangdong Modern Agricultural Research System 2022KJ126School-level Innovation and Entrepreneurship Training Program for College Students Sycxcy2023087Scientific Research Foundation of Shaoguan University for the Introduction of Talents 99000639
6 · The paper itself

Abstract

Tert-butylhydroquinone (tBHQ) has emerged as a promising candidate for mitigating the adverse effects of T-2-induced reproductive toxicity. The protective effects of tBHQ on rat sperm quality, testicular injury, apoptosis, and inflammation induced by T-2 toxin exposure were investigated. Histopathological examination of testicular tissues revealed severe damage in the T-2-treated group, characterized by disorganized germ cell arrangement, thinning of the convoluted seminiferous tubule walls, and significant cellular necrosis. However, tBHQ administration, either as a preventive or therapeutic measure, mitigated this structural damage. Image analysis confirmed an increase in the cross-sectional area and height of the convoluted seminiferous tubules in the tBHQ-treated groups compared to the T-2-treated group (

Indexed as

apoptosisinflammationoxidative stressT-2tert-butylhydroquinonetestis

Identifiers

PMID38787114
PMCPMC11125982

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.