Evidence map›Paper›PMID 38786968›Full record

ArticleJournal of cardiovascular development and disease2024

Role of Lipoprotein Ratios and Remnant Cholesterol in Patients with Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA).

Vincenzo Sucato, Luca Di Fazio, Cristina Madaudo, Giuseppe Vadalà, Alessandro D'Agostino, Salvatore Evola, Giuseppina Novo, Egle Corrado, Alfredo Ruggero Galassi

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Article in Journal of cardiovascular development and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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0cells of the map it votes in
3citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Vincenzo SucatoDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University Hospital "Paolo Giaccone", University of Palermo, 90133 Palermo, Italy.ORCID 0000-0001-9514-1575
Luca Di FazioDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University Hospital "Paolo Giaccone", University of Palermo, 90133 Palermo, Italy.
Cristina MadaudoDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University Hospital "Paolo Giaccone", University of Palermo, 90133 Palermo, Italy.ORCID 0000-0002-9151-4335
Giuseppe VadalàDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University Hospital "Paolo Giaccone", University of Palermo, 90133 Palermo, Italy.
Alessandro D'AgostinoDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University Hospital "Paolo Giaccone", University of Palermo, 90133 Palermo, Italy.
Salvatore EvolaDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University Hospital "Paolo Giaccone", University of Palermo, 90133 Palermo, Italy.
Giuseppina NovoDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University Hospital "Paolo Giaccone", University of Palermo, 90133 Palermo, Italy.
Egle CorradoDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University Hospital "Paolo Giaccone", University of Palermo, 90133 Palermo, Italy.
Alfredo Ruggero GalassiDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University Hospital "Paolo Giaccone", University of Palermo, 90133 Palermo, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMyocardial infarction with non-obstructive coronary arteries (MINOCA) is a clinical situation characterized by evidence of acute myocardial infarction (AMI)-according to the Fourth Universal Definition of Myocardial Infarction-with normal or near-normal coronary arteries on angiographic study (stenosis < 50%). This condition is extremely variable in etiology, pathogenic mechanisms, clinical manifestations, prognosis and consequently therapeutic approach.

objectiveThe objective of the study was the evaluation of remnant cholesterol (RC), monocyte/high-density lipoprotein cholesterol ratio (MHR), platelet/lymphocyte ratio (PLR) and various lipoprotein ratios in patients with MINOCA in order to establish their validity as predictors of this event. MATERIALS AND

methodsWe included 114 patients hospitalized in the Intensive Coronary Care Unit (ICCU) and Hospital Wards of our Hospital Center from 2015 to 2019 who received a diagnosis of MINOCA compared to a control group of 110 patients without previous cardiovascular events. RC was calculated with the following formula: RC = total cholesterol (TC) - HDL-C - LDL-C. MHR was calculated by dividing the monocyte count in peripheral blood by high-density lipoprotein cholesterol (HDL-C) levels; PLR was obtained by dividing platelet count by lymphocyte count. We also calculated various lipoprotein ratios, like total cholesterol/high-density lipoprotein cholesterol (TC/HDL-C), low-density lipoprotein cholesterol/high-density lipoprotein cholesterol (LDL-C/HDL-C), triglycerides/high-density lipoprotein cholesterol (TG/HDL-C), and non-high-density lipoprotein cholesterol/high-density lipoprotein cholesterol (non-HDL-C/HDL-C) ratios.

resultsThe MINOCA group had higher mean levels of RC (21.3 ± 10.6 vs. 13.2 ± 7.7 mg/dL), MHR (23 ± 0.009 vs. 18.5± 8.3) and PLR (179.8 ± 246.1 vs. 135 ± 64.7) than the control group. Only the mean values of all calculated lipoprotein ratios were lower in MINOCA patients. Statistical significance was achieved only in the RC evaluation.

conclusionsHigher levels of RC and MHR were found in patients with MINOCA. We also observed higher levels of PLR than in the control group. Only various lipoprotein ratios were lower, but this could reflect the extreme heterogeneity underlying the pathogenic mechanisms of MINOCA. In patients who receive a diagnosis of MINOCA with a baseline alteration of the lipid profile and higher levels of cholesterol at admission as well, the evaluation of these parameters could play an important role, providing more detailed information about their cardiometabolic risk.

Indexed as

dyslipidemialipoprotein ratioMINOCAremnant cholesterol

Identifiers

PMID38786968
PMCPMC11122552

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