Evidence map›Paper›PMID 38786947›Full record

ArticleMembranes2024

Can Storage Stability and Simulated Gastrointestinal Behavior Change the Cytotoxic Effects of Concentrated Guava Leaves Extract against Human Lung Cancer Cells?

Giordana Demaman Arend, Silvani Verruck, Naira Fernanda Zanchett Schneider, Cláudia Maria Oliveira Simões, Marcus Vinícius Tres, Elane Schwinden Prudêncio, José Carlos Cunha Petrus, Katia Rezzadori

Abstract read
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In one paragraph

Article in Membranes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Giordana Demaman ArendDepartment of Chemical and Food Engineering, Federal University of Santa Catarina, Florianópolis 88040-900, SC, Brazil.
Silvani VerruckDepartment of Food Science and Technology, Federal University of Santa Catarina, Av. Ademar Gonzaga, 1346, Itacorubi, Florianópolis 88034-000, SC, Brazil.ORCID 0000-0003-0266-5885
Naira Fernanda Zanchett SchneiderLaboratory of Applied Virology, Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Florianópolis 88035-972, SC, Brazil.
Cláudia Maria Oliveira SimõesLaboratory of Applied Virology, Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Florianópolis 88035-972, SC, Brazil.
Marcus Vinícius TresLaboratory of Agroindustrial Processes Engineering-LAPE, Federal University of Santa Maria, Cachoeira do Sul 96503-205, RS, Brazil.ORCID 0000-0001-5252-0735
Elane Schwinden PrudêncioDepartment of Food Science and Technology, Federal University of Santa Catarina, Av. Ademar Gonzaga, 1346, Itacorubi, Florianópolis 88034-000, SC, Brazil.
José Carlos Cunha PetrusDepartment of Chemical and Food Engineering, Federal University of Santa Catarina, Florianópolis 88040-900, SC, Brazil.
Katia RezzadoriDepartment of Food Science and Technology, Federal University of Santa Catarina, Av. Ademar Gonzaga, 1346, Itacorubi, Florianópolis 88034-000, SC, Brazil.

Funding

CAPES 001CNPq 407877/2018-5
6 · The paper itself

Abstract

The influence of storage stability and simulated gastrointestinal behavior of different extracts of guava leaves extracts (NC: not concentrated, and C10 and C20: concentrated by nanofiltration) was evaluated based on their total phenolic compound (TPC) contents and antioxidant activity as well as on their cytotoxic effects on A549 and Vero cells. The results showed that C10 and C20 presented high stability for 125 days probably due to their high TPC contents and antioxidant activity. The simulated gastrointestinal behavior modified their TPC contents; however, after all digestion steps, the TPC values were higher than 70%, which means that they were still available to exert their bioactivities. Additionally, the cytotoxic effects of these extracts were evaluated before and after the simulated gastrointestinal behavior or under different storage conditions. C10 presented the best selectivity indices (SI) values (IC50 Vero cells/IC50 A549 cells) at both conditions suggesting that it can be considered a potential extract to be developed as a functional food due to its resistance to the gastrointestinal digestion and storage conditions tested.

Indexed as

antioxidant activitycytoprotective effectlung carcinomaphenolic compoundsPsidium guajava L. leaves

Identifiers

PMID38786947
PMCPMC11123244

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.