Evidence map›Paper›PMID 38786705›Full record

ArticleJournal of fungi (Basel, Switzerland)2024

Genome Mining of Fungal Unique Trichodiene Synthase-like Sesquiterpene Synthases.

Zhanren Cong, Qiang Yin, Kunhong Tian, Njeru Joe Mukoma, Liming Ouyang, Tom Hsiang, Lixin Zhang, Lan Jiang, Xueting Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhanren CongState Key Laboratory of Bioreactor Engineering, East China University of Science of Technology, Shanghai 200237, China.ORCID 0009-0008-4589-2336
Qiang YinState Key Laboratory of Bioreactor Engineering, East China University of Science of Technology, Shanghai 200237, China.
Kunhong TianState Key Laboratory of Bioreactor Engineering, East China University of Science of Technology, Shanghai 200237, China.
Njeru Joe MukomaState Key Laboratory of Bioreactor Engineering, East China University of Science of Technology, Shanghai 200237, China.
Liming OuyangState Key Laboratory of Bioreactor Engineering, East China University of Science of Technology, Shanghai 200237, China.ORCID 0000-0003-3507-7895
Tom HsiangSchool of Environmental Sciences, University of Guelph, 50 Stone Road East, Guelph, ON N1G 2W1, Canada.
Lixin ZhangState Key Laboratory of Bioreactor Engineering, East China University of Science of Technology, Shanghai 200237, China.
Lan JiangDepartment of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical University, Nanjing 210093, China.
Xueting LiuState Key Laboratory of Bioreactor Engineering, East China University of Science of Technology, Shanghai 200237, China.

Funding

Key Technologies Research and Development Program 2019YFA0906200Key Technologies Research and Development Program 2020YFA090032National Natural Science Foundation of China 21907031National Natural Science Foundation of China 21977029The National Key Research and Development Program 2022YFC2105400
6 · The paper itself

Abstract

Sesquiterpenoids served as an important source for natural product drug discovery. Although genome mining approaches have revealed numerous novel sesquiterpenoids and biosynthetic enzymes, the comprehensive landscape of fungal sesquiterpene synthases (STSs) remains elusive. In this study, 123 previously reported fungal STSs were subjected to phylogenetic analysis, resulting in the identification of a fungi-specific STS family known as trichodiene synthase-like sesquiterpene synthases (TDTSs). Subsequently, the application of hidden Markov models allowed the discovery of 517 TDTSs from our in-house fungi genome library of over 400 sequenced genomes, and these TDTSs were defined into 79 families based on a sequence similarity network. Based on the novelty of protein sequences and the completeness of their biosynthetic gene clusters, 23

Indexed as

fungigenome miningmonoterpenessesquiterpenessesquiterpene synthasetrichodiene synthase

Identifiers

PMID38786705
PMCPMC11122449

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.