Evidence map›Paper›PMID 38786628›Full record

ArticleJournal of functional biomaterials2024

Cell Instructive Behavior of Composite Scaffolds in a Co-Culture of Human Mesenchymal Stem Cells and Peripheral Blood Mononuclear Cells.

Georgia-Ioanna Kontogianni, Amedeo Franco Bonatti, Carmelo De Maria, Raasti Naseem, Catarina Coelho, Kalliopi Alpantaki, Aristea Batsali, Charalampos Pontikoglou, Paulo Quadros, Kenneth Dalgarno and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of functional biomaterials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Georgia-Ioanna KontogianniDepartment of Materials Science and Engineering, University of Crete, 70013 Heraklion, Greece.
Amedeo Franco BonattiResearch Center E. Piaggio, Department of Information Engineering, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0001-7177-5135
Carmelo De MariaResearch Center E. Piaggio, Department of Information Engineering, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-1368-3571
Raasti NaseemSchool of Engineering, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.ORCID 0000-0003-1978-4370
Catarina CoelhoFLUIDINOVA, S.A., 4475-188 Maia, Portugal.ORCID 0000-0002-7049-8030
Kalliopi AlpantakiDepartment of Orthopaedics and Trauma, Venizeleion General Hospital of Heraklion, 70013 Heraklion, Greece.ORCID 0000-0003-0185-8474
Aristea BatsaliHemopoiesis Research Laboratory, School of Medicine, University of Crete, 70013 Heraklion, Greece.
Charalampos PontikoglouHemopoiesis Research Laboratory, School of Medicine, University of Crete, 70013 Heraklion, Greece.
Paulo QuadrosFLUIDINOVA, S.A., 4475-188 Maia, Portugal.ORCID 0000-0002-7207-1110
Kenneth DalgarnoSchool of Engineering, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.
Giovanni VozziResearch Center E. Piaggio, Department of Information Engineering, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-9414-9994
Chiara Vitale-BrovaroneDepartment of Applied Science and Technology, Politecnico di Torino, 10129 Turin, Italy.
Maria ChatzinikolaidouDepartment of Materials Science and Engineering, University of Crete, 70013 Heraklion, Greece.ORCID 0000-0002-2749-2506

Funding

European Commission 814410
6 · The paper itself

Abstract

The in vitro evaluation of 3D scaffolds for bone tissue engineering in mono-cultures is a common practice; however, it does not represent the native complex nature of bone tissue. Co-cultures of osteoblasts and osteoclasts, without the addition of stimulating agents for monitoring cellular cross-talk, remains a challenge. In this study, a growth factor-free co-culture of human bone marrow-derived mesenchymal stem cells (hBM-MSCs) and human peripheral blood mononuclear cells (hPBMCs) has been established and used for the evaluation of 3D-printed scaffolds for bone tissue engineering. The scaffolds were produced from PLLA/PCL/PHBV polymeric blends, with two composite materials produced through the addition of 2.5%

Indexed as

3D-printed scaffoldsbioactive scaffoldsbone tissue engineeringnanohydroxyapatiteosteoclastogenesisosteogenesisPCLPHBVPLLAstrontium

Identifiers

PMID38786628
PMCPMC11122527

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.