Evidence map›Paper›PMID 38786562›Full record

ArticleJournal of imaging2024

Optimizing Vision Transformers for Histopathology: Pretraining and Normalization in Breast Cancer Classification.

Giulia Lucrezia Baroni, Laura Rasotto, Kevin Roitero, Angelica Tulisso, Carla Di Loreto, Vincenzo Della Mea

Abstract read
In one paragraph

Article in Journal of imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Giulia Lucrezia BaroniDepartment of Mathematics, Computer Science and Physics, University of Udine, 33100 Udine, Italy.ORCID 0009-0004-0150-7468
Laura RasottoDepartment of Mathematics, Computer Science and Physics, University of Udine, 33100 Udine, Italy.ORCID 0009-0001-4615-4772
Kevin RoiteroDepartment of Mathematics, Computer Science and Physics, University of Udine, 33100 Udine, Italy.ORCID 0000-0002-9191-3280
Angelica TulissoIstituto di Anatomia Patologica, Azienda Sanitaria Universitaria Friuli Centrale, 33100 Udine, Italy.
Carla Di LoretoIstituto di Anatomia Patologica, Azienda Sanitaria Universitaria Friuli Centrale, 33100 Udine, Italy.
Vincenzo Della MeaDepartment of Mathematics, Computer Science and Physics, University of Udine, 33100 Udine, Italy.ORCID 0000-0002-0144-3802

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This paper introduces a self-attention Vision Transformer model specifically developed for classifying breast cancer in histology images. We examine various training strategies and configurations, including pretraining, dimension resizing, data augmentation and color normalization strategies, patch overlap, and patch size configurations, in order to evaluate their impact on the effectiveness of the histology image classification. Additionally, we provide evidence for the increase in effectiveness gathered through geometric and color data augmentation techniques. We primarily utilize the BACH dataset to train and validate our methods and models, but we also test them on two additional datasets, BRACS and AIDPATH, to verify their generalization capabilities. Our model, developed from a transformer pretrained on ImageNet, achieves an accuracy rate of 0.91 on the BACH dataset, 0.74 on the BRACS dataset, and 0.92 on the AIDPATH dataset. Using a model based on the prostate small and prostate medium HistoEncoder models, we achieve accuracy rates of 0.89 and 0.86, respectively. Our results suggest that pretraining on large-scale general datasets like ImageNet is advantageous. We also show the potential benefits of using domain-specific pretraining datasets, such as extensive histopathological image collections as in HistoEncoder, though not yet with clear advantages.

Indexed as

breast cancerdeep learninghistologynormalizationtransformers

Identifiers

PMID38786562
PMCPMC11121856

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.