Effects of Oleanolic Acid Derived from Wine Pomace on Periodontopathic Bacterial Growth in Healthy Individuals: A Randomized Placebo-Controlled Study.

Kyoko Shimazu, Kouta Ookoshi, Satoshi Fukumitsu, Hiroyuki Kagami, Chieko Mitsuhata, Ryota Nomura, Kazuhiko Aida

Abstract read

In one paragraph

Article in Dentistry journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

From Waste to Beauty: Agri-Food By-Products as Sources of Antioxidant Compounds for Cosmeceutical Applications.Antioxidants (Basel, Switzerland) · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kyoko ShimazuInnovation Center, Central Research Laboratory, Nippn Corporation, Yokohama 243-0041, Japan.

Kouta OokoshiInnovation Center, Central Research Laboratory, Nippn Corporation, Yokohama 243-0041, Japan.

Satoshi FukumitsuInnovation Center, Central Research Laboratory, Nippn Corporation, Yokohama 243-0041, Japan.

Hiroyuki KagamiKagami Dental Office, Kitahiroshima 061-1134, Japan.

Chieko MitsuhataDepartment of Pediatric Dentistry, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.

Ryota NomuraDepartment of Pediatric Dentistry, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.

Kazuhiko AidaInnovation Center, Central Research Laboratory, Nippn Corporation, Yokohama 243-0041, Japan.

Funding

Nippn Corporation NA

6 · The paper itself

Abstract

Periodontal disease is caused by oral pathogenic bacteria and is associated with systemic disease and frailty. Therefore, its prevention is crucial in extending healthy life expectancy. This study aimed to evaluate the effect of orally administered oleanolic acid, extracted from wine pomace, on periodontopathic bacterial growth in healthy individuals. In this randomized, placebo-controlled, double-blind, parallel-group comparison study, 84 healthy adults were assigned to a placebo (

Indexed as

oleanolic acidoral microbiomeperiodontal diseaseperiodontopathic bacteriawine pomace

Identifiers

PMID38786531

DOI10.3390/dj12050133

PMCPMC11119493

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.