Evidence map›Paper›PMID 38786006›Full record

ArticleBiomolecules2024

3-Hydroxyanthranilic Acid Delays Paralysis in

Bradford T Hull, Kayla M Miller, Caroline Corban, Grant Backer, Susan Sheehan, Ron Korstanje, George L Sutphin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bradford T HullMolecular and Cellular Biology Department, University of Arizona, Tucson, AZ 85721, USA.
Kayla M MillerCancer Biology Graduate Interdisciplinary Program, University of Arizona, Tucson, AZ 85721, USA.ORCID 0000-0002-7811-3975
Caroline CorbanThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
Grant BackerThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
Susan SheehanThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
Ron KorstanjeThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
George L SutphinMolecular and Cellular Biology Department, University of Arizona, Tucson, AZ 85721, USA.ORCID 0000-0002-3659-4678

Funding

Translational CoreP30AG038070 · NIA · JACKSON LABORATORY · PI Gary A Churchill · 2010 to 2026
$19.3M
Defining the genetic architecture of multi-stress responseR35GM133588 · NIGMS · UNIVERSITY OF ARIZONA · PI George Lewis Sutphin · 2019 to 2026
$3.0M
NIA NIH HHS P30 AG038070NIGMS NIH HHS R35 GM133588NIH HHS 1R35GM133588-01A1NIH HHS 2P30AG038070-06A2
6 · The paper itself

Abstract

Age is the primary risk factor for neurodegenerative diseases such as Alzheimer's and Huntington's disease. Alzheimer's disease is the most common form of dementia and a leading cause of death in the elderly population of the United States. No effective treatments for these diseases currently exist. Identifying effective treatments for Alzheimer's, Huntington's, and other neurodegenerative diseases is a major current focus of national scientific resources, and there is a critical need for novel therapeutic strategies. Here, we investigate the potential for targeting the kynurenine pathway metabolite 3-hydroxyanthranilic acid (3HAA) using

Indexed as

3-Hydroxyanthranilic AcidAmyloid beta-PeptidesCaenorhabditis elegansParalysisPeptidesAlzheimer DiseaseAnimalsCaenorhabditis elegans ProteinsDioxygenasesDisease Models, AnimalHuntington Disease3-Hydroxyanthranilic AcidAmyloid beta-PeptidesCaenorhabditis elegans ProteinsDioxygenasesPeptidespolyglutamineAlzheimer’s diseaseCaenorhabditis elegansHuntington’s diseasekynureninemetabolismneurodegenerationproteotoxicitytryptophan

Identifiers

PMID38786006
PMCPMC11117628

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.