Evidence map›Paper›PMID 38785974›Full record

ArticleBiomolecules2024

Astrogliosis in the GFAP-Cre

Colin Rorex, Sandra M Cardona, Kaira A Church, Derek Rodriguez, Difernando Vanegas, Reina Saldivar, Brianna Faz, Astrid E Cardona

Abstract read
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Colin RorexMolecular Microbiology and Immunology, College of Sciences, The University of Texas at San Antonio, San Antonio, TX 78249, USA.
Sandra M CardonaMolecular Microbiology and Immunology, College of Sciences, The University of Texas at San Antonio, San Antonio, TX 78249, USA.ORCID 0000-0001-9128-6742
Kaira A ChurchMolecular Microbiology and Immunology, College of Sciences, The University of Texas at San Antonio, San Antonio, TX 78249, USA.ORCID 0000-0002-3982-8476
Derek RodriguezMolecular Microbiology and Immunology, College of Sciences, The University of Texas at San Antonio, San Antonio, TX 78249, USA.ORCID 0000-0002-1354-9735
Difernando VanegasMolecular Microbiology and Immunology, College of Sciences, The University of Texas at San Antonio, San Antonio, TX 78249, USA.
Reina SaldivarMolecular Microbiology and Immunology, College of Sciences, The University of Texas at San Antonio, San Antonio, TX 78249, USA.
Brianna FazIntegrative Biology, The University of Texas at San Antonio, San Antonio, TX 78249, USA.
Astrid E CardonaMolecular Microbiology and Immunology, College of Sciences, The University of Texas at San Antonio, San Antonio, TX 78249, USA.ORCID 0000-0002-5093-8078

Funding

UTSA RISE Research Training ProgramR25GM060655 · NIGMS · UNIVERSITY OF TEXAS SAN ANTONIO · PI BAREA-RODRIGUEZ, EDWIN J · 2000 to 2022
$21.6M
Microglia Mediated Inflammation in the Diabetic RetinaR01EY029913 · NEI · UNIVERSITY OF TEXAS SAN ANTONIO · PI CARDONA, ASTRID E · 2019 to 2022
$1.6M
MARC at the University of Texas at San AntonioT34GM145507 · NIGMS · UNIVERSITY OF TEXAS SAN ANTONIO · PI BAREA-RODRIGUEZ, EDWIN J, CASSILL, AARON · 2022 to 2024
$1.5M
NEI NIH HHS R01 EY029913NIGMS NIH HHS R25 GM060655NIGMS NIH HHS T34 GM145507the Jane and Roland Blumberg Professorship in Biology and the South Texas Center for Emerging Infectious Diseases Ph.D. scholarship E00004
6 · The paper itself

Abstract

Diabetic retinopathy (DR) affects over 140 million people globally. The mechanisms that lead to blindness are still enigmatic but there is evidence that sustained inflammation and hypoxia contribute to vascular damage. Despite efforts to understand the role of inflammation and microglia in DR's pathology, the contribution of astrocytes to hypoxic responses is less clear. To investigate the role of astrocytes in hypoxia-induced retinopathy, we utilized a 7-day systemic hypoxia model using the GFAP-Cre

Indexed as

Disease Models, AnimalEpendymoglial CellsGliosisMice, TransgenicMicrogliaAnimalsAstrocytesCytokinesDiabetic RetinopathyDiphtheria ToxinGlial Fibrillary Acidic ProteinHypoxiaMiceRetinaVimentinCytokinesDiphtheria ToxinGlial Fibrillary Acidic Proteinglial fibrillary astrocytic protein, mouseVimentinastrocytesdiabetic retinopathyfibrinogenhypoxiainflammationmicrogliaMüller glia

Identifiers

PMID38785974
PMCPMC11117533

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.