Evidence map›Paper›PMID 38785944›Full record

ArticleBiomolecules2024

Glycosylation Modulation Dictates Trafficking and Interaction of SARS-CoV-2 S1 Subunit and ACE2 in Intestinal Epithelial Caco-2 Cells.

Marianne El Khoury, Dalanda Wanes, Maura Lynch-Miller, Abdullah Hoter, Hassan Y Naim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Molecules (Basel, Switzerland) · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marianne El KhouryDepartment of Biochemistry, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
Dalanda WanesDepartment of Biochemistry, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.ORCID 0000-0002-6788-7414
Maura Lynch-MillerDepartment of Biochemistry, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.ORCID 0009-0004-9070-8770
Abdullah HoterDepartment of Biochemistry, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.
Hassan Y NaimDepartment of Biochemistry, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.ORCID 0000-0003-4884-8425

Funding

Deutsche Forschungsgemeinschaft NA331/15-1
6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mainly targets the upper respiratory tract. It gains entry by interacting with the host cell receptor angiotensin-converting enzyme 2 (ACE2) via its heavily glycosylated spike glycoprotein. SARS-CoV-2 can also affect the gastrointestinal tract. Given the significant role of glycosylation in the life cycle of proteins and the multisystem target of SARS-CoV-2, the role of glycosylation in the interaction of S1 with ACE2 in Caco-2 cells was investigated after modulation of their glycosylation patterns using

Indexed as

Angiotensin-Converting Enzyme 2SARS-CoV-2Spike Glycoprotein, Coronavirus1-DeoxynojirimycinAnimalsCaco-2 CellsCHO CellsCOVID-19CricetulusGlycosylationHumansIntestinal MucosaProtein BindingProtein Transport1-DeoxynojirimycinACE2 protein, humanAngiotensin-Converting Enzyme 2Spike Glycoprotein, Coronavirusspike protein, SARS-CoV-2glycosylationN-butyldeoxynojirimycinprotein–protein interactionprotein traffickingSARS-CoV-2

Identifiers

PMID38785944
PMCPMC11117975

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.