Evidence map›Paper›PMID 38785930›Full record

ArticleBiomolecules2024

Herpesvirus Entry Mediator as an Immune Checkpoint Target and a Potential Prognostic Biomarker in Myeloid and Lymphoid Leukemia.

Fatemah S Basingab, Reem A Alzahrani, Aisha A Alrofaidi, Ahmed S Barefah, Rawan M Hammad, Hadil M Alahdal, Jehan S Alrahimi, Kawther A Zaher, Ali H Algiraigri, Mai M El-Daly and 2 more

Abstract read
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fatemah S BasingabDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21859, Saudi Arabia.ORCID 0000-0001-5251-559X
Reem A AlzahraniDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21859, Saudi Arabia.
Aisha A AlrofaidiDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21859, Saudi Arabia.ORCID 0000-0002-0416-2723
Ahmed S BarefahHematology Department, Faculty of Medicine, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah 21859, Saudi Arabia.ORCID 0000-0003-2009-3817
Rawan M HammadHematology Department, Faculty of Medicine, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah 21859, Saudi Arabia.
Hadil M AlahdalDepartment of Biology, Faculty of Science, Princes Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia.
Jehan S AlrahimiDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21859, Saudi Arabia.ORCID 0000-0001-7803-2078
Kawther A ZaherImmunology Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21859, Saudi Arabia.ORCID 0000-0003-0909-6558
Ali H AlgiraigriHematology Department, Faculty of Medicine, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah 21859, Saudi Arabia.
Mai M El-DalySpecial Infectious Agents Unit-BSL3, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21859, Saudi Arabia.ORCID 0000-0002-3864-523X
Saleh A AlkarimDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21859, Saudi Arabia.ORCID 0000-0002-2217-1615
Alia M AldahlawiDepartment of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21859, Saudi Arabia.ORCID 0000-0001-9599-050X

Funding

the Ministry of Education and Deanship of Scientific Research (DSR) at King Abdulaziz Univer-sity (KAU), Jeddah. IFPRC‑217-130-2020
6 · The paper itself

Abstract

Herpesvirus entry mediator (HVEM) is a molecular switch that can modulate immune responses against cancer. The significance of HVEM as an immune checkpoint target and a potential prognostic biomarker in malignancies is still controversial. This study aims to determine whether HVEM is an immune checkpoint target with inhibitory effects on anti-tumor CD4

Indexed as

Biomarkers, TumorReceptors, Tumor Necrosis Factor, Member 14AdultAgedCD4-Positive T-LymphocytesCell Line, TumorCell ProliferationFemaleHEK293 CellsHumansK562 CellsMaleMiddle AgedPrecursor Cell Lymphoblastic Leukemia-LymphomaPrognosisYoung AdultBiomarkers, TumorReceptors, Tumor Necrosis Factor, Member 14TNFRSF14 protein, humanacute lymphocytic leukemiaCD4+ T cellsco-inhibitory moleculesherpesvirus entry mediatorimmune checkpoint blockadeimmune checkpoint receptor

Identifiers

PMID38785930
PMCPMC11117912

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.