Evidence map›Paper›PMID 38785802›Full record

ArticleBiology2024

Early Animal Origin of BACE1 APP/Aβ Proteolytic Function.

James A Langeland, Lillian Baumann, Eva M DeYoung, Raphaela Angelina Varella, Nkatha Mwenda, Alejandro Aguirre, D Blaine Moore

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

James A LangelandDepartment of Biology, Kalamazoo College, 1200 Academy Street, Kalamazoo, MI 49006, USA.
Lillian BaumannDepartment of Biology, Kalamazoo College, 1200 Academy Street, Kalamazoo, MI 49006, USA.
Eva M DeYoungDepartment of Biology, Kalamazoo College, 1200 Academy Street, Kalamazoo, MI 49006, USA.
Raphaela Angelina VarellaDepartment of Biology, Kalamazoo College, 1200 Academy Street, Kalamazoo, MI 49006, USA.
Nkatha MwendaDepartment of Biology, Kalamazoo College, 1200 Academy Street, Kalamazoo, MI 49006, USA.
Alejandro AguirreDepartment of Biology, Kalamazoo College, 1200 Academy Street, Kalamazoo, MI 49006, USA.
D Blaine MooreDepartment of Biology, Kalamazoo College, 1200 Academy Street, Kalamazoo, MI 49006, USA.ORCID 0009-0003-6669-1246

Funding

National Science Foundation RUI 1817867
6 · The paper itself

Abstract

Alzheimer's disease is characterized, in part, by the accumulation of β-amyloid (Aβ) in the brain. Aβ is produced via the proteolysis of APP by BACE1 and γ-secretase. Since BACE1 is the rate-limiting enzyme in the production of Aβ, and a target for therapeutics, it is of interest to know when its proteolytic function evolved and for what purpose. Here, we take a functional evolutionary approach to show that BACE1 likely evolved from a gene duplication event near the base of the animal clade and that BACE1 APP/Aβ proteolytic function evolved during early animal diversification, hundreds of millions of years before the evolution of the APP/Aβ substrate. Our examination of BACE1 APP/Aβ proteolytic function includes cnidarians, ctenophores, and choanoflagellates. The most basal BACE1 ortholog is found in cnidarians, while ctenophores, placozoa, and choanoflagellates have genes equally orthologous to BACE1 and BACE2. BACE1 from a cnidarian (

Indexed as

amyloid precursor protein (APP)animalBACEevolutionβ-amyloid (Aβ)

Identifiers

PMID38785802
PMCPMC11117577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.