Evidence map›Paper›PMID 38785721›Full record

ArticleBiosensors2024

A Copper-Selective Sensor and Its Inhibition of Copper-Amyloid Beta Aggregation.

Ngoc Kim Nguyen, Bella Poduska, Mia Franks, Manoranjan Bera, Ian MacCormack, Guoxing Lin, Alexander P Petroff, Samir Das, Arundhati Nag

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ngoc Kim NguyenCarlson School of Chemistry and Biochemistry, Clark University, 950 Main Street, Worcester, MA 01610, USA.
Bella PoduskaCarlson School of Chemistry and Biochemistry, Clark University, 950 Main Street, Worcester, MA 01610, USA.
Mia FranksCarlson School of Chemistry and Biochemistry, Clark University, 950 Main Street, Worcester, MA 01610, USA.ORCID 0009-0004-4303-4590
Manoranjan BeraCarlson School of Chemistry and Biochemistry, Clark University, 950 Main Street, Worcester, MA 01610, USA.ORCID 0009-0003-1885-7627
Ian MacCormackCarlson School of Chemistry and Biochemistry, Clark University, 950 Main Street, Worcester, MA 01610, USA.
Guoxing LinCarlson School of Chemistry and Biochemistry, Clark University, 950 Main Street, Worcester, MA 01610, USA.ORCID 0000-0002-5841-5669
Alexander P PetroffCarlson School of Chemistry and Biochemistry, Clark University, 950 Main Street, Worcester, MA 01610, USA.
Samir DasCarlson School of Chemistry and Biochemistry, Clark University, 950 Main Street, Worcester, MA 01610, USA.
Arundhati NagCarlson School of Chemistry and Biochemistry, Clark University, 950 Main Street, Worcester, MA 01610, USA.ORCID 0000-0002-1328-1695

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Copper is an essential trace metal for biological processes in humans and animals. A low level of copper detection at physiological pH using fluorescent probes is very important for in vitro applications, such as the detection of copper in water or urine, and in vivo applications, such as tracking the dynamic copper concentrations inside cells. Copper homeostasis is disrupted in neurological diseases like Alzheimer's disease, and copper forms aggregates with amyloid beta (Ab42) peptide, resulting in senile plaques in Alzheimer's brains. Therefore, a selective copper detector probe that can detect amyloid beta peptide-copper aggregates and decrease the aggregate size has potential uses in medicine. We have developed a series of Cu

Indexed as

Amyloid beta-PeptidesCopperAlzheimer DiseaseBiosensing TechniquesChelating AgentsFluorescent DyesHumansProtein AggregatesAmyloid beta-PeptidesChelating AgentsCopperFluorescent DyesProtein AggregatesCu-amyloid betafluorescent copper chelatornon-amyloid aggregate inhibition

Identifiers

PMID38785721
PMCPMC11117483

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.