Evidence map›Paper›PMID 38785423›Full record

ArticleJournal of virology2024

Host obesity impacts genetic variation in influenza A viral populations.

Marissa Knoll, Rebekah Honce, Victoria Meliopoulos, Ernesto Alejandro Segredo-Otero, Katherine E E Johnson, Stacey Schultz-Cherry, Elodie Ghedin, David Gresham

Abstract read
In one paragraph

Article in Journal of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Marissa KnollDepartment of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, USA.
Rebekah HonceDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Victoria MeliopoulosDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0003-1442-9177
Ernesto Alejandro Segredo-OteroDepartment of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, USA.
Katherine E E JohnsonSystems Genomics Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, Maryland, USA.
Stacey Schultz-CherryDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0002-2021-727X
Elodie GhedinSystems Genomics Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, Maryland, USA.ORCID 0000-0002-1515-725X
David GreshamDepartment of Biology, Center for Genomics and Systems Biology, New York University, New York, New York, USA.ORCID 0000-0002-4028-0364

Funding

NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00016 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI WEBBY, RICHARD · 2021 to 2025
$91.4M
COVID Supplement - COMPONENT A OF THE COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTERS (CIVICS) PROGRAM TO DESIGN AND EVALUATE INNOVATIVE INFLUENZA VACCINE APPROACHES,75N93019C00052 · NIAID · UNIVERSITY OF GEORGIA · PI ROSS, TED · 2019 to 2025
$74.6M
Genomic profiling of influenza infections to identify biomarkers of disease severityZIAAI001323 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GHEDIN, ELODIE · 2020 to 2025
$8.0M
Effects of obesity on the dynamics of Influenza transmissionR01AI140766 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI GRESHAM, DAVID, SCHULTZ-CHERRY, STACEY L · 2019 to 2023
$4.1M
The Quantitative Biological Systems Training (QBIST) ProgramT32GM132037 · NIGMS · NEW YORK UNIVERSITY · PI David Gresham, Christine Vogel · 2019 to 2026
$2.3M
Regulated and evolutionary responses to nutritional stressR35GM153419 · NIGMS · NEW YORK UNIVERSITY · PI David Gresham · 2024 to 2026
$1.8M
Constraints and Consequences of Copy Number VariationR01GM134066 · NIGMS · NEW YORK UNIVERSITY · PI GRESHAM, DAVID · 2020 to 2023
$1.2M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI140766HHS | NIH | National Institute of General Medical Sciences (NIGMS) R01GM134066HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM153419HHS | NIH | National Institute of General Medical Sciences (NIGMS) T32GM132037NIAID NIH HHS 75N93019C00052NIAID NIH HHS 75N93021C00016NIAID NIH HHS R01 AI140766NIGMS NIH HHS R01 GM134066NIGMS NIH HHS R35 GM153419NIGMS NIH HHS T32 GM132037
6 · The paper itself

Abstract

Obesity is well established as a risk factor for many noncommunicable diseases; however, its consequences for infectious disease are poorly understood. Here, we investigated the impact of host obesity on influenza A virus (IAV) genetic variation using a diet-induced obesity ferret model and the A/Hong Kong/1073/1999 (H9N2) strain. Using a co-caging study design, we investigated the maintenance, generation, and transmission of intrahost IAV genetic variation by sequencing viral genomic RNA obtained from nasal wash samples over multiple days of infection. We found evidence for an enhanced role of positive selection acting on

Indexed as

FerretsGenetic VariationGenome, ViralInfluenza A virusObesityOrthomyxoviridae InfectionsAnimalsDisease Models, AnimalEvolution, MolecularHost Microbial InteractionsHumansMaleMutationRNA-Dependent RNA PolymeraseRNA, ViralThinnessinfluenza virus polymerase basic protein 1PB2 protein, Influenzavirus ARNA-Dependent RNA PolymeraseRNA, ViralViral Proteinsferretgenetic diversityinfluenzaobesity

Identifiers

PMID38785423
PMCPMC11237528

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.