Evidence map›Paper›PMID 38784735›Full record

ArticleChemical science2024

Photochemical and biological dual-effects enhance the inhibition of photosensitizers for tumour growth.

Huiyu Niu, Yang Liu, Yafu Wang, Yonggang Yang, Ge Wang, Tony D James, Jonathan L Sessler, Hua Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Huiyu NiuKey Laboratory of Green Chemical Media and Reactions, Ministry of Education, Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals, Organic Functional Molecules and Drug Innovation Key Laboratory of Henan Province, School of Chemistry and Chemical Engineering, Henan Normal University Xinxiang Henan 453007 P. R. China zhh1106@htu.edu.cn +86-373-3329030 +86-373-3329030.
Yang LiuKey Laboratory of Green Chemical Media and Reactions, Ministry of Education, Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals, Organic Functional Molecules and Drug Innovation Key Laboratory of Henan Province, School of Chemistry and Chemical Engineering, Henan Normal University Xinxiang Henan 453007 P. R. China zhh1106@htu.edu.cn +86-373-3329030 +86-373-3329030.
Yafu WangKey Laboratory of Green Chemical Media and Reactions, Ministry of Education, Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals, Organic Functional Molecules and Drug Innovation Key Laboratory of Henan Province, School of Chemistry and Chemical Engineering, Henan Normal University Xinxiang Henan 453007 P. R. China zhh1106@htu.edu.cn +86-373-3329030 +86-373-3329030.
Yonggang YangKey Laboratory of Green Chemical Media and Reactions, Ministry of Education, Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals, Organic Functional Molecules and Drug Innovation Key Laboratory of Henan Province, School of Chemistry and Chemical Engineering, Henan Normal University Xinxiang Henan 453007 P. R. China zhh1106@htu.edu.cn +86-373-3329030 +86-373-3329030.
Ge WangCollege of Basic Medicine, Xinxiang Medical University Xinxiang Henan 453007 P. R. China.
Tony D JamesKey Laboratory of Green Chemical Media and Reactions, Ministry of Education, Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals, Organic Functional Molecules and Drug Innovation Key Laboratory of Henan Province, School of Chemistry and Chemical Engineering, Henan Normal University Xinxiang Henan 453007 P. R. China zhh1106@htu.edu.cn +86-373-3329030 +86-373-3329030.ORCID https://orcid.org/0000-0002-4095-2191
Jonathan L SesslerDepartment of Chemistry, The University of Texas at Austin Austin 78712 USA sessler@cm.utexas.edu.ORCID https://orcid.org/0000-0002-9576-1325
Hua ZhangKey Laboratory of Green Chemical Media and Reactions, Ministry of Education, Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals, Organic Functional Molecules and Drug Innovation Key Laboratory of Henan Province, School of Chemistry and Chemical Engineering, Henan Normal University Xinxiang Henan 453007 P. R. China zhh1106@htu.edu.cn +86-373-3329030 +86-373-3329030.ORCID https://orcid.org/0000-0002-7593-4946

Funding

Biomedical Applications of Expanded Porphyrins: Development of Gold-Texaphyrin ConjugatesR01CA068682 · NCI · UNIVERSITY OF TEXAS AUSTIN · PI Esther Y. Maier, Emily L Que · 1995 to 2026
$7.4M
NCI NIH HHS R01 CA068682
6 · The paper itself

Abstract

Photosensitizers typically rely on a singular photochemical reaction to generate reactive oxygen species, which can then inhibit or eradicate lesions. However, photosensitizers often exhibit limited therapeutic efficiency due to their reliance on a single photochemical effect. Herein, we propose a new strategy that integrates the photochemical effect (type-I photochemical effect) with a biological effect (proton sponge effect). To test our strategy, we designed a series of photosensitizers (ZZ-sers) based on the naphthalimide molecule. ZZ-sers incorporate both a

Identifiers

PMID38784735
PMCPMC11110147

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.