Evidence map›Paper›PMID 38784723›Full record

ArticleJBMR plus2024

Sex dimorphic response to osteocyte miR21 deletion in murine calvaria bone as determined by RNAseq analysis.

Gang Peng, Padmini Deosthale, Roquelina Pianeta, Hannah M Messersmith, Lilian I Plotkin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JBMR plus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gang PengDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
Padmini DeosthaleDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
Roquelina PianetaIndiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
Hannah M MessersmithDepartment of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
Lilian I PlotkinIndiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN 46202, United States.

Funding

Osteocyte Apoptosis and Regulation of Bone Resorption with AgingR01AR067210 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI PLOTKIN, LILIAN IRENE · 2015 to 2019
$1.9M
Contribution of chromosome versus gonadal sex to bone mass and strengthR21AG078861 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI PLOTKIN, LILIAN IRENE · 2022 to 2023
$832k
Skeletal complications to a TREM2 variant associated with Alzheimer's DiseaseI01BX005154 · VA · RLR VA MEDICAL CENTER · PI PLOTKIN, LILIAN IRENE · 2021 to 2024
–
BLRD VA I01 BX005154NIAMS NIH HHS R01 AR067210NIA NIH HHS R21 AG078861
6 · The paper itself

Abstract

Low levels of microRNA (miR) 21 may explain the higher osteocyte apoptosis with Cx43-deficient and aged female mice. However, miR21 exerts a sex-divergent role in osteocytes, regulating bone mass and architecture through non-cell autonomous effects on osteoblasts and osteoclasts, via sex-specific regulation of osteocyte cytokine production. miR21 deficiency improves bone strength in females, and, to a higher extent, in male miR21-deficient mice. To understand the molecular basis for the effects of miR21 deletion, mRNA was isolated from miR21

Identifiers

PMID38784723
PMCPMC11114469

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.