Evidence map›Paper›PMID 38784722›Full record

ArticleJBMR plus2024

Bone health, cardiovascular disease, and imaging outcomes in UK Biobank: a causal analysis.

Dorina-Gabriela Condurache, Stefania D'Angelo, Ahmed M Salih, Liliana Szabo, Celeste McCracken, Adil Mahmood, Elizabeth M Curtis, Andre Altmann, Steffen E Petersen, Nicholas C Harvey and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JBMR plus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dorina-Gabriela ConduracheNIHR Barts Biomedical Research Centre, William Harvey Research Institute, Centre for Advanced Cardiovascular Imaging, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, England, United Kingdom.
Stefania D'AngeloMRC Lifecourse Epidemiology Centre, University of Southampton, Tremona Road, Southampton SO16 6YD, England,United Kingdom.
Ahmed M SalihNIHR Barts Biomedical Research Centre, William Harvey Research Institute, Centre for Advanced Cardiovascular Imaging, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, England, United Kingdom.
Liliana SzaboNIHR Barts Biomedical Research Centre, William Harvey Research Institute, Centre for Advanced Cardiovascular Imaging, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, England, United Kingdom.
Celeste McCrackenDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, National Institute for Health Research Oxford Biomedical Research Centre, University of Oxford, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 9DU, England, United Kingdom.
Adil MahmoodNIHR Barts Biomedical Research Centre, William Harvey Research Institute, Centre for Advanced Cardiovascular Imaging, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, England, United Kingdom.
Elizabeth M CurtisMRC Lifecourse Epidemiology Centre, University of Southampton, Tremona Road, Southampton SO16 6YD, England,United Kingdom.
Andre AltmannDepartment of Medical Physics and Biomedical Engineering, Centre for Medical Image Computing (CMIC), University College London, London WC1E 6BT, England, United Kingdom.
Steffen E PetersenNIHR Barts Biomedical Research Centre, William Harvey Research Institute, Centre for Advanced Cardiovascular Imaging, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, England, United Kingdom.
Nicholas C HarveyMRC Lifecourse Epidemiology Centre, University of Southampton, Tremona Road, Southampton SO16 6YD, England,United Kingdom.
Zahra Raisi-EstabraghNIHR Barts Biomedical Research Centre, William Harvey Research Institute, Centre for Advanced Cardiovascular Imaging, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, England, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study examined the association of estimated heel bone mineral density (eBMD, derived from quantitative ultrasound) with: (1) prevalent and incident cardiovascular diseases (CVDs: ischemic heart disease (IHD), myocardial infarction (MI), heart failure (HF), non-ischemic cardiomyopathy (NICM), arrhythmia), (2) mortality (all-cause, CVD, IHD), and (3) cardiovascular magnetic resonance (CMR) measures of left ventricular and atrial structure and function and aortic distensibility, in the UK Biobank. Clinical outcomes were ascertained using health record linkage over 12.3 yr of prospective follow-up. Two-sample Mendelian randomization (MR) was conducted to assess causal associations between BMD and CMR metrics using genetic instrumental variables identified from published genome-wide association studies. The analysis included 485 257 participants (55% women, mean age 56.5

Indexed as

BMDbone healthcardiovascular diseasescardiovascular imagingcardiovascular magnetic resonanceheel ultrasoundMendelian randomizationosteoporosis

Identifiers

PMID38784722
PMCPMC11114472

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.