Evidence map›Paper›PMID 38784593›Full record

ArticleFrontiers in public health2024

Clinical and serological predictors of post COVID-19 condition-findings from a Canadian prospective cohort study.

Erin Collins, Yannick Galipeau, Corey Arnold, Anne Bhéreur, Ronald Booth, Arianne C Buchan, Curtis Cooper, Angela M Crawley, Pauline S McCluskie, Michaeline McGuinty and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Autoantibodies targeting angiotensin-converting enzyme 2 are prevalent and not induced by SARS-CoV-2 infection.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Erin CollinsSchool of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Yannick GalipeauDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.
Corey ArnoldDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.
Anne BhéreurFaculty of Medicine, University of Montreal, Montreal, QC, Canada.
Ronald BoothFaculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Arianne C BuchanFaculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Curtis CooperFaculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Angela M CrawleyDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.
Pauline S McCluskieDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.
Michaeline McGuintyFaculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Martin PelchatDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.
Lynda RocheleauDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.
Raphael SaginurFaculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Chris GravelSchool of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Steven HawkenSchool of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Marc-André LangloisDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.
Julian LittleSchool of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: More than 3 years into the pandemic, there is persisting uncertainty as to the etiology, biomarkers, and risk factors of Post COVID-19 Condition (PCC). Serological research data remain a largely untapped resource. Few studies have investigated the potential relationships between post-acute serology and PCC, while accounting for clinical covariates. Methods: We compared clinical and serological predictors among COVID-19 survivors with ( Results: Similar proportions of PCC-cases (66.7%, Conclusion: Despite past COVID-19 infection, approximately one third of PCC-cases and infected-controls were seronegative for anti-N IgG. Findings suggest higher neutralization efficiency among cases as compared with controls, and that this relationship is stronger among cases with more severe PCC. Cases also required more medical support for COVID-19 symptoms, and described complex, ongoing health sequelae. More data from larger cohorts are needed to substantiate results, permit subgroup analyses of IgG titres, and explore for differences between clusters of PCC symptoms. Future assessment of IgG subtypes may also elucidate new findings.

Indexed as

COVID-19Immunoglobulin GSARS-CoV-2AdultAgedAntibodies, ViralBiomarkersCanadaFemaleHumansMaleMiddle AgedPost-Acute COVID-19 SyndromeProspective StudiesRisk FactorsSpike Glycoprotein, CoronavirusAntibodies, ViralBiomarkersImmunoglobulin GSpike Glycoprotein, CoronavirusantibodiesCOVID-19IgGlong COVIDneutralizationpost COVID-19 conditionSARS-CoV-2serology

Identifiers

PMID38784593
PMCPMC11111987

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.