ArticleFrontiers in public health2024
mNGS helped diagnose scrub typhus-associated HLH in children: a report of two cases.
Article in Frontiers in public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- A rare case of scrub typhus complicated by severe hemolytic anemia, septic shock, and multi-organ dysfunction in a patient with thalassemia.Tropical medicine and health · 2026Article
- High infant mortality, eschar absence, and universal CNS involvement in scrub typhus-associated HLH: a case series and narrative synthesis of 91 pediatric cases.Tropical medicine and health · 2026Article
- Article
- Advancing the diagnosis of scrub typhus with targeted next-generation sequencing.Frontiers in microbiology · 2026Article
- Severe paediatric scrub typhus with complications: a case report and literature review.BMC pediatrics · 2025Review
- Recurrent acute appendicitis after recovery from scrub typhus that was associated with hemophagocytic lymphohistiocytosis and other severe complications in children: a case report.Frontiers in medicine · 2025Article
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Authors and funding
10 authors.
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Abstract
Background: Scrub typhus, caused by the Case presentation: We obtained clinical data from two patients in the South of Sichuan, China. The first case involved a 6-year-old girl who exhibited an unexplained fever and was initially diagnosed with sepsis, HLH, and pulmonary infection. The other patient presented a more severe condition characterized by multiple organ dysfunction and was initially diagnosed with septic shock, sepsis, HLH, acute kidney injury (AKI), and pulmonary infection. At first, a specific examination for scrub typhus was not performed due to the absence of a characteristic eschar. Conventional peripheral blood cultures yielded negative results in both patients, and neither of them responded to routine antibiotics. Fortunately, the causative pathogen Conclusion: The unbiased mNGS provided a clinically actionable diagnosis for an uncommon pathogen-associated infectious disease that had previously evaded conventional diagnostic approaches.
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