Evidence map›Paper›PMID 38784500›Full record

ArticleEthiopian journal of health sciences2023

Prevalence of Non-Tuberculosis Mycobacterium Pulmonary Disease in HIV-1 Patients with Presumptive Pulmonary Tuberculosis in Western Kenya.

Anne Ochayo, Ronald Wamalwa, Erick Barasa, Jeremiah Zablon, George Sowayi, Tom Were, Godfrey Gitonga, Nathan Shaviya

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Article in Ethiopian journal of health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anne OchayoDepartment of Medical Laboratory Sciences, School of Public Health, Biomedical Science and Technology, Masinde Muliro University, P.O. Box 190-50100, Kakamega, Kenya.
Ronald WamalwaDepartment of Medical Laboratory Sciences, School of Public Health, Biomedical Science and Technology, Masinde Muliro University, P.O. Box 190-50100, Kakamega, Kenya.
Erick BarasaDepartment of Medical Laboratory Sciences, School of Public Health, Biomedical Science and Technology, Masinde Muliro University, P.O. Box 190-50100, Kakamega, Kenya.
Jeremiah ZablonNational Tuberculosis Reference Laboratory & Kenyatta National Hospital, P.O Box 20723-00202, Nairobi, Kenya.
George SowayiDepartment of Medical Laboratory Sciences, School of Public Health, Biomedical Science and Technology, Masinde Muliro University, P.O. Box 190-50100, Kakamega, Kenya.
Tom WereDepartment of Microbiology and Parasitology, School of Medicine, Masinde Muliro University, P.O. Box 190-50100, Kakamega Kenya.
Godfrey GitongaDepartment of Medical Laboratory Sciences, School of Public Health, Biomedical Science and Technology, Masinde Muliro University, P.O. Box 190-50100, Kakamega, Kenya.
Nathan ShaviyaDepartment of Medical Laboratory Sciences, School of Public Health, Biomedical Science and Technology, Masinde Muliro University, P.O. Box 190-50100, Kakamega, Kenya.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Non-tuberculous mycobacteria (NTMs) are ubiquitous, free-living, environmental saprophytic microorganisms. NTMs belong to the genus Mycobacterium which includes Mycobacterium tuberculosis (MTB). NTMs have lately been a major cause of pulmonary disease (PD) in immuno-compromised individuals including HIV-1 patients. NTMs and MTB appear similar based on microscopy, radiology, and clinical symptoms; consequently, this may lead to misdiagnosis. This study sought to establish the prevalence of NTM pulmonary disease in HIV-1 patients presumed to have pulmonary tuberculosis. Methods: A cross-sectional analytical laboratory study design was used targeting 617 adult HIV-1 infected patients presenting with presumptive pulmonary TB at Bungoma County Hospital Comprehensive Care Clinic in Western Kenya between July 2021 to June 2022. Results: A total of 75 (12.2%, 4.6 -9.8 CI) of the participants presented with presumptive MTB and had TB-like symptoms while 542 (87.8%, 12.5 -30.7 CI) were negative. Additionally, 56 (9.1%) were infected with NTMs. HIV-positive participants had a significantly higher prevalence of NTMs 62 (11.8%, 5.6 -9.2 CI) compared to 2 (2.1%, 0.4 -1.8 CI). In HIV + study participants P<0.0001. M. avium was the most prevalent NTM, 25(33.3%), followed by M. fortuitum 20 (26.7%). A significant number of the isolates were M. tuberculosis 10 (13.3%) as well as M. kansasii 8 (10.7%). Conclusion: There seems to be a high prevalence of NTMPD in HIV-1 patients which is assumed to be pulmonary TB. Differential diagnosis of the mycobacterium species is necessary to help improve disease management and outcomes in this group of patients.

Indexed as

HIV-1HIV InfectionsMycobacterium Infections, NontuberculousNontuberculous MycobacteriaTuberculosis, PulmonaryAdultCross-Sectional StudiesFemaleHumansKenyaMaleMiddle AgedPrevalenceYoung AdultHIV-1non-tuberculous mycobacteriumPulmonary tuberculosis

Identifiers

PMID38784500
PMCPMC11111211

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.