Evidence map›Paper›PMID 38784379›Full record

ArticleFrontiers in immunology2024

A bioinformatic analysis of T-cell epitope diversity in SARS-CoV-2 variants: association with COVID-19 clinical severity in the United States population.

Grace J Kim, Jacob H Elnaggar, Mallory Varnado, Amy K Feehan, Darlene Tauzier, Rebecca Rose, Susanna L Lamers, Maya Sevalia, Najah Nicholas, Elizabeth Gravois and 3 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Grace J KimDepartment of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA, United States.
Jacob H ElnaggarSchool of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, United States.
Mallory VarnadoSchool of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, United States.
Amy K FeehanResearch and Development, Oschner Medical Center, New Orleans, LA, United States.
Darlene TauzierDepartment of Pathology, Louisiana State University Health Sciences Center, New Orleans, LA, United States.
Rebecca RoseResearch and Development, BioInfoExperts, LLC, Thibodaux, LA, United States.
Susanna L LamersResearch and Development, BioInfoExperts, LLC, Thibodaux, LA, United States.
Maya SevaliaSchool of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, United States.
Najah NicholasSchool of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, United States.
Elizabeth GravoisDepartment of Pathology, Louisiana State University Health Sciences Center, New Orleans, LA, United States.
Daniel FortResearch and Development, Oschner Medical Center, New Orleans, LA, United States.
Judy S CrabtreeDepartment of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA, United States.
Lucio MieleDepartment of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA, United States.

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
NRSA Training CoreTL1TR003106 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SAAG, KENNETH G · 2019 to 2023
$3.7M
NCATS NIH HHS TL1 TR003106NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

Long-term immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires the identification of T-cell epitopes affecting host immunogenicity. In this computational study, we explored the CD8

Indexed as

Computational BiologyCOVID-19Epitopes, T-LymphocyteSARS-CoV-2AllelesCD8-Positive T-LymphocytesHLA-A AntigensHLA-B AntigensHumansSeverity of Illness IndexSpike Glycoprotein, CoronavirusUnited StatesEpitopes, T-LymphocyteHLA-A AntigensHLA-B AntigensSpike Glycoprotein, CoronavirusbioinformaticsCD8 T cell epitopeCOVID-19HLASARS-CoV-2T cell epitopevaccine design

Identifiers

PMID38784379
PMCPMC11112498

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.