Evidence map›Paper›PMID 38784114›Full record

ReviewFrontiers in physiology2024

Are the class 18 myosins Myo18A and Myo18B specialist sarcomeric proteins?

Markus Horsthemke, Charles-Adrien Arnaud, Peter J Hanley

Abstract readReview
In one paragraph

Review in Frontiers in physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Markus HorsthemkeIMM Institute for Molecular Medicine, HMU Health and Medical University Potsdam, Potsdam, Germany.
Charles-Adrien ArnaudIMM Institute for Molecular Medicine, HMU Health and Medical University Potsdam, Potsdam, Germany.
Peter J HanleyIMM Institute for Molecular Medicine, HMU Health and Medical University Potsdam, Potsdam, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Initially, the two members of class 18 myosins, Myo18A and Myo18B, appeared to exhibit highly divergent functions, complicating the assignment of class-specific functions. However, the identification of a striated muscle-specific isoform of Myo18A, Myo18Aγ, suggests that class 18 myosins may have evolved to complement the functions of conventional class 2 myosins in sarcomeres. Indeed, both genes,

Indexed as

knockout (KO) miceMYO18AMYO18Bsarcomerestress fibersunconventional myosins

Identifiers

PMID38784114
PMCPMC11112018

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.